{"id":"W2114025189","doi":"10.1002/anie.200502179","title":"Thiooligosaccharide Conjugate Vaccines Evoke Antibodies Specific for Native Antigens","year":2005,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Glycoside; Conjugate; Antibody; Antigen; Antibody response; Conjugate vaccine; Virology; Biology; Immunology; Chemistry; Immunogenicity; Stereochemistry; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718709,0.0001447378,0.0001088423,0.00009129167,0.0001145996,0.00006259803,0.0002059384,0.0001132195,0.000331096],"category_scores_gemma":[0.0001729028,0.000140848,0.0001116637,0.00006075064,0.00005176372,0.00002935472,0.00006561033,0.0000848934,0.00004987755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004622708,"about_ca_system_score_gemma":0.00004396074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009292429,"about_ca_topic_score_gemma":0.00003667653,"domain_scores_codex":[0.998976,0.0000140961,0.0002170525,0.0003257813,0.0002569229,0.0002101801],"domain_scores_gemma":[0.9991134,0.00002847501,0.00009353868,0.0001585789,0.0005411237,0.00006486234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002158874,0.00007365044,0.0004777228,0.0000119401,0.0000821638,0.000001459682,0.00006411204,0.00004642288,0.9145127,0.0005750968,0.08170507,0.002233808],"study_design_scores_gemma":[0.0005791574,0.0000542608,0.0008027327,0.00001222929,0.000003835762,0.000007495647,0.00003849065,0.0001123054,0.6639285,0.0002288233,0.3341202,0.0001119822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8893048,0.001630384,0.06106858,0.01289116,0.002746672,0.001429718,0.001378011,0.0001180783,0.02943264],"genre_scores_gemma":[0.9870706,0.0009012887,0.001490499,0.0004901706,0.004225479,0.0001022967,0.002255244,0.00002225841,0.003442114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2524151,"threshold_uncertainty_score":0.5743615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02160439450004988,"score_gpt":0.3042457743857079,"score_spread":0.282641379885658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}