{"id":"W2114055896","doi":"10.1002/smll.200801572","title":"Antitumor Activity and Prolonged Survival by Carbon‐Nanotube‐Mediated Therapeutic siRNA Silencing in a Human Lung Xenograft Model","year":2009,"lang":"en","type":"article","venue":"Small","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":240,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Biotechnology and Biological Sciences Research Council","keywords":"In vivo; Gene silencing; Liposome; Cationic liposome; Cytotoxicity; Small interfering RNA; Transfection; Cancer research; Apoptosis; Carbon nanotube; Materials science; In vitro; Pharmacology; Nanotechnology; Chemistry; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492015,0.0003870174,0.0002963733,0.0001871211,0.000108208,0.000149784,0.0001588936,0.0003576284,0.000848217],"category_scores_gemma":[0.00007770361,0.00009351233,0.0001994521,0.000117087,0.0001292916,0.0001455949,0.00009566919,0.0003378637,0.000233103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122204,"about_ca_system_score_gemma":0.0002568788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176836,"about_ca_topic_score_gemma":0.001295633,"domain_scores_codex":[0.9999073,0.0000160983,0.000009211184,0.00002304399,0.00002773677,0.00001665749],"domain_scores_gemma":[0.9999125,0.00001791565,0.00002380939,0.00001145213,0.00001734752,0.00001692766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009512535,0.00003864081,0.00005457164,0.00001168966,0.000002772161,0.00001811242,0.000006712679,0.00007887666,0.9990087,0.00001922224,0.00002658897,0.0006390436],"study_design_scores_gemma":[0.00001047949,0.0009203288,0.001058336,0.000001808125,0.00001144393,0.0001046354,0.000006621231,0.001056305,0.9962372,0.00001017435,0.0005804784,0.000002322961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929081,0.001179869,0.00403903,0.00008444213,0.00003568341,0.00005086302,0.0003250588,0.0001291846,0.001247848],"genre_scores_gemma":[0.9931282,0.0006806684,0.002609895,0.00003221602,0.000006488328,0.00008119491,0.0006145153,0.00002154404,0.002825431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001176836,"threshold_uncertainty_score":0.002837539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434004461125176,"score_gpt":0.2506078929910387,"score_spread":0.2362678483797869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}