{"id":"W2114081556","doi":"10.1194/jlr.m011726","title":"Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway","year":2011,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Nova Scotia Health Research Foundation","keywords":"Apolipoprotein B; Endoplasmic-reticulum-associated protein degradation; Endoplasmic reticulum; Very low-density lipoprotein; Ubiquitin; Microsomal triglyceride transfer protein; Ubiquitin ligase; Gene knockdown; Cell biology; Chemistry; Small interfering RNA; Secretion; Endocrinology; Internal medicine; Biology; Unfolded protein response; Biochemistry; Lipoprotein; Transfection; Apoptosis; Cholesterol; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001185864,0.0002317249,0.0003014294,0.0001708853,0.000284633,0.0004146508,0.0001186233,0.0002007334,0.001590203],"category_scores_gemma":[0.00008486622,0.0001597149,0.0003152616,0.0002495735,0.0002173,0.0001862721,0.0001514312,0.0004274641,0.0009684999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004123207,"about_ca_system_score_gemma":0.0002229631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002028138,"about_ca_topic_score_gemma":0.00198801,"domain_scores_codex":[0.9998412,0.00002366402,0.00002264835,0.00003527375,0.0000419557,0.00003526857],"domain_scores_gemma":[0.9999418,0.00000701111,0.00001120071,0.00001164812,0.00001341019,0.00001495488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002974472,0.00004186898,0.0004557454,0.00003889179,0.000004462499,0.00007348655,0.00001735236,0.00005237727,0.9979057,0.00006166326,0.00009084984,0.0009600901],"study_design_scores_gemma":[0.00003150825,0.0001329872,0.01192797,0.00000457972,0.0000133034,0.0001889751,0.00005626883,0.001346406,0.9839147,0.00003628332,0.002340265,0.000006781335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988584,0.002540677,0.003110975,0.0002155204,0.00008756079,0.00004198701,0.001055639,0.0002056301,0.004157878],"genre_scores_gemma":[0.9890744,0.001028561,0.001901897,0.0000857978,0.00001435008,0.00005809512,0.001305463,0.00003696062,0.006494564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002028138,"threshold_uncertainty_score":0.005319715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04145598636451098,"score_gpt":0.3086424854756553,"score_spread":0.2671864991111443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}