{"id":"W2114085390","doi":"10.1371/journal.pone.0007208","title":"Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Occupational Cancer Research Centre; University of Toronto","funders":"National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; National Institutes of Health; W. Garfield Weston Foundation","keywords":"Biology; Phylogenetic tree; Gene; Genetics; Protein family; Sequence alignment; Homology (biology); Transmembrane domain; Peptide sequence; Phylogenetics; Conserved sequence; Protein domain; Transmembrane protein; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005785261,0.00006596922,0.0001074771,0.00001107284,0.00002657332,0.000002097535,0.000119824,0.0000514024,0.00001687201],"category_scores_gemma":[0.00001485544,0.0000515905,0.00008731446,0.00003787569,0.00003536006,0.000002399004,0.00001413648,0.00002999815,8.475917e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004888866,"about_ca_system_score_gemma":0.00003093421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003321606,"about_ca_topic_score_gemma":0.000002379375,"domain_scores_codex":[0.9994584,0.00003132897,0.0001554794,0.0001262663,0.0001465328,0.00008197584],"domain_scores_gemma":[0.999649,0.000007030882,0.00007519603,0.0001914142,0.00004782023,0.0000295481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001260258,0.0003462014,0.003443104,0.00001456166,0.000112628,4.857383e-7,0.00002401234,0.00001060646,0.9850636,0.00002495139,0.00004286983,0.01079103],"study_design_scores_gemma":[0.0002447198,0.0001876116,0.1191695,0.00006197677,0.000116768,2.105101e-7,0.00002981309,0.00004794301,0.8796523,0.0001552641,0.0002688718,0.00006499338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973954,0.02530307,0.00029987,0.0001727614,0.00001492029,0.0001469693,0.00006696225,0.000004049435,0.00003745329],"genre_scores_gemma":[0.9937192,0.004704845,0.00123494,0.0001219755,0.00008175059,0.000004088807,0.0001176748,0.000004912632,0.00001059848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1157264,"threshold_uncertainty_score":0.21038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622440940750149,"score_gpt":0.2142799483438521,"score_spread":0.1880555389363506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}