{"id":"W2114085390","doi":"10.1371/journal.pone.0007208","title":"Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Occupational Cancer Research Centre; University of Toronto","funders":"National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; National Institutes of Health; W. Garfield Weston Foundation","keywords":"Biology; Phylogenetic tree; Gene; Genetics; Protein family; Sequence alignment; Homology (biology); Transmembrane domain; Peptide sequence; Phylogenetics; Conserved sequence; Protein domain; Transmembrane protein; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002413462,0.0001866456,0.0002339506,0.0004662386,0.0003402365,0.0004346498,0.0002294811,0.0003725221,0.0005255117],"category_scores_gemma":[0.0002936292,0.0001441367,0.0002132152,0.0002643666,0.0003519645,0.0004031605,0.0004866477,0.0004897647,0.0004463103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003271624,"about_ca_system_score_gemma":0.0002164472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004610872,"about_ca_topic_score_gemma":0.0005742717,"domain_scores_codex":[0.9999058,0.00001025088,0.000006426535,0.00003196393,0.00002545462,0.00002001839],"domain_scores_gemma":[0.9998648,0.00002002424,0.00003072218,0.00001606714,0.00003610572,0.00003221776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007584203,0.0000846688,0.03280256,0.0001699644,0.00005133508,0.003421325,0.0007124741,0.0006061646,0.8946221,0.007074198,0.0002652923,0.0594315],"study_design_scores_gemma":[0.0002055324,0.001232674,0.6642758,0.000167416,0.0002024473,0.03314159,0.001282886,0.009947558,0.2078429,0.01366755,0.06785803,0.0001755762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886068,0.002365011,0.006378552,0.0002195031,0.00001956748,0.00002898343,0.00009036535,0.00005231347,0.002238989],"genre_scores_gemma":[0.9880697,0.001893444,0.007064846,0.0001482632,0.00002597326,0.00001745118,0.0003785809,0.00001946831,0.002382263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005255117,"threshold_uncertainty_score":0.002373695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622440940750149,"score_gpt":0.2142799483438521,"score_spread":0.1880555389363506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}