{"id":"W2114104841","doi":"10.1101/sqb.2011.76.010868","title":"Control of Glycolysis through Regulation of PFK1: Old Friends and Recent Additions","year":2011,"lang":"en","type":"review","venue":"Cold Spring Harbor Symposia on Quantitative Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":310,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Phosphofructokinase; Glycolysis; Phosphofructokinase 2; Phosphofructokinase 1; Fructose; Enzyme; Metabolism; Biochemistry; Fructose 2,6-bisphosphate; Metabolic pathway; Biology; Flux (metallurgy); Carbohydrate metabolism; Enzyme activator; Cell biology; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002850451,0.0003278984,0.001026779,0.00016537,0.00006107885,0.000006730951,0.0001890694,0.000511433,0.00003149522],"category_scores_gemma":[0.0001978957,0.0002949488,0.0002648311,0.0001966069,0.00028531,0.000005177854,0.00007549151,0.0001373735,0.000004168304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002592521,"about_ca_system_score_gemma":0.0001163776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003517536,"about_ca_topic_score_gemma":0.000007748088,"domain_scores_codex":[0.998059,0.0003778439,0.000730173,0.0005399425,0.00008237316,0.0002106421],"domain_scores_gemma":[0.998122,0.0001752907,0.0009038546,0.0004671144,0.00027448,0.00005727056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008170936,0.0001093283,0.0001109766,0.0008522553,0.000527284,3.655158e-7,0.00002924481,0.000004511534,0.06823573,0.9214251,0.000009222159,0.008614256],"study_design_scores_gemma":[0.0004425606,0.001440251,0.0003681617,0.0009684942,0.0005562202,3.174268e-7,0.000005862742,0.00001378627,0.0175723,0.0001864257,0.9781469,0.0002987733],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002560209,0.9912304,0.004624839,0.00001248712,0.0001913285,0.0005836535,0.0004224293,0.000008519129,0.0003661461],"genre_scores_gemma":[0.0376886,0.9600761,0.001834822,0.00001480273,0.00006875305,0.0001041048,0.0001443037,0.00004115889,0.00002733975],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9781376,"threshold_uncertainty_score":0.9999503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04764502834025379,"score_gpt":0.3295279888278217,"score_spread":0.2818829604875679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}