{"id":"W2114114329","doi":"10.1021/bi902079y","title":"Crystal Structure of the Catalytic Domain of Human PARP2 in Complex with PARP Inhibitor ABT-888","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Diamond Light Source; Wellcome Trust","keywords":"Poly ADP ribose polymerase; PARP1; NAD+ kinase; Polymerase; DNA; Chromatin; Chemistry; PARP inhibitor; Ribose; DNA repair; ADP-ribosylation; Biochemistry; DNA damage; Enzyme; Transcription (linguistics); Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007025948,0.000140239,0.0002663759,0.00003169748,0.00003287679,0.000004118934,0.0001583968,0.0001446198,0.0003105178],"category_scores_gemma":[0.00002105892,0.0000951449,0.00006647668,0.0001736629,0.0004511519,0.00001893522,0.00003596245,0.000325993,7.353167e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005100189,"about_ca_system_score_gemma":0.0001761443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005341283,"about_ca_topic_score_gemma":0.00007806133,"domain_scores_codex":[0.9990373,0.00001327361,0.000303942,0.0001991672,0.000287544,0.0001587544],"domain_scores_gemma":[0.9990888,0.00002143322,0.0001988541,0.000541883,0.00008362894,0.00006546623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001279492,0.00008625803,0.02604162,0.0002437093,0.00002472317,0.000003936603,0.0002039397,0.000001137616,0.9722802,0.00005887203,0.0008979693,0.00002965525],"study_design_scores_gemma":[0.002120199,0.00006922123,0.03099878,0.0001844745,0.00001984352,0.0000588946,0.0001844312,0.000003207314,0.9656942,0.0002306302,0.0003377206,0.0000984018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978796,0.00004783389,0.000003315511,0.0002656873,0.00005922234,0.0002008267,0.0001266869,0.00001287473,0.001403945],"genre_scores_gemma":[0.9991053,0.000001250749,0.0003854535,0.00008672339,0.0001841155,0.000007205508,0.0000672227,0.00001808042,0.0001446961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006586029,"threshold_uncertainty_score":0.3879896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170174487711837,"score_gpt":0.2735198795656024,"score_spread":0.261818134688484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}