{"id":"W2114114329","doi":"10.1021/bi902079y","title":"Crystal Structure of the Catalytic Domain of Human PARP2 in Complex with PARP Inhibitor ABT-888","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Diamond Light Source; Wellcome Trust","keywords":"Poly ADP ribose polymerase; PARP1; NAD+ kinase; Polymerase; DNA; Chromatin; Chemistry; PARP inhibitor; Ribose; DNA repair; ADP-ribosylation; Biochemistry; DNA damage; Enzyme; Transcription (linguistics); Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855181,0.0004272209,0.0004849325,0.0001466771,0.000406983,0.0005568319,0.0008538959,0.0005274631,0.002438159],"category_scores_gemma":[0.0003022063,0.000301649,0.0001911222,0.0003294311,0.0002278106,0.0002835671,0.0001805024,0.001347709,0.0005057903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009586539,"about_ca_system_score_gemma":0.0006781048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005508506,"about_ca_topic_score_gemma":0.005799034,"domain_scores_codex":[0.9998029,0.0000199168,0.000008411426,0.0000451997,0.0000867617,0.00003679518],"domain_scores_gemma":[0.9998753,0.00003193264,0.00002193179,0.000005124442,0.0000286583,0.00003702732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004509048,0.001822867,0.009312966,0.0008411959,0.0005335602,0.004330295,0.0006133353,0.01360914,0.9053694,0.003418361,0.03374385,0.021896],"study_design_scores_gemma":[0.004423595,0.001927949,0.1134231,0.0002347404,0.0005736222,0.008537712,0.001206406,0.1414811,0.5980258,0.001797948,0.1281044,0.0002636538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769504,0.00555029,0.001760894,0.001369679,0.0002050547,0.00006365751,0.003517387,0.0002606943,0.01032184],"genre_scores_gemma":[0.9707655,0.002515105,0.0040194,0.00047466,0.00005380477,0.00006358667,0.01335326,0.00009062717,0.008664083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005508506,"threshold_uncertainty_score":0.01095289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170174487711837,"score_gpt":0.2735198795656024,"score_spread":0.261818134688484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}