{"id":"W2114127218","doi":"10.1093/carcin/bgt284","title":"Synergistic anti-breast cancer effect of a combined treatment with the methyl donor<i>S</i>-adenosyl methionine and the DNA methylation inhibitor 5-aza-2′-deoxycytidine","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Demethylating agent; DNA methylation; Cancer research; DNA demethylation; Epigenetics; Cancer; Decitabine; Methylation; Biology; Azacitidine; DNA; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004885497,0.0002783606,0.0003885455,0.00005125492,0.0001856074,0.0000403074,0.0001530015,0.0001235969,0.00002543302],"category_scores_gemma":[0.00005353962,0.0001309193,0.0001307979,0.0002004291,0.0003206635,0.000009580878,0.00007496675,0.0000620312,0.00000211368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003082315,"about_ca_system_score_gemma":0.00006105909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009401386,"about_ca_topic_score_gemma":0.00009625076,"domain_scores_codex":[0.9984868,0.0004675841,0.0002678472,0.0003555584,0.0001980708,0.0002241363],"domain_scores_gemma":[0.9987689,0.0002666651,0.0002093192,0.000462123,0.0002141734,0.00007882809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000467939,0.00003145078,0.01458234,0.00004064004,0.0002767507,5.470787e-7,0.000109079,0.0002548406,0.976708,0.00006445833,0.00005938009,0.007404581],"study_design_scores_gemma":[0.002847434,0.0008416529,0.0552338,0.00001713518,0.0004533764,0.000003546695,0.00004681885,0.0002588097,0.9397511,0.0000340692,0.0003442226,0.000167983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863098,0.01033095,0.0005277198,0.001720473,0.00008831192,0.0009111881,0.0000518231,0.000009803676,0.00004987848],"genre_scores_gemma":[0.9973955,0.001628547,0.00009285494,0.00006901546,0.0001983173,0.0003948882,0.00006107358,0.00003394283,0.0001258464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04065146,"threshold_uncertainty_score":0.5338734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005566890296630092,"score_gpt":0.223860886322396,"score_spread":0.2182939960257659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}