{"id":"W2114127218","doi":"10.1093/carcin/bgt284","title":"Synergistic anti-breast cancer effect of a combined treatment with the methyl donor<i>S</i>-adenosyl methionine and the DNA methylation inhibitor 5-aza-2′-deoxycytidine","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Demethylating agent; DNA methylation; Cancer research; DNA demethylation; Epigenetics; Cancer; Decitabine; Methylation; Biology; Azacitidine; DNA; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001767879,0.0004698589,0.0007648158,0.000377108,0.0001297127,0.0002548684,0.0003079048,0.000376772,0.001906467],"category_scores_gemma":[0.0001209264,0.0002169983,0.0004148483,0.000301305,0.00018344,0.0001334517,0.000220231,0.0005980648,0.0004605488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844256,"about_ca_system_score_gemma":0.0003755721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006604305,"about_ca_topic_score_gemma":0.001972396,"domain_scores_codex":[0.9998372,0.0000419721,0.00001371372,0.00002821283,0.00003492475,0.00004404969],"domain_scores_gemma":[0.9999167,0.00002204289,0.00001028072,0.00001121445,0.000007915397,0.00003190842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002536257,0.0006932751,0.0004506143,0.0002567573,0.0001162895,0.0001832045,0.00004549049,0.0003923472,0.9786828,0.0001332484,0.0003721626,0.01613764],"study_design_scores_gemma":[0.000394738,0.0114564,0.006460382,0.00002213227,0.0002523773,0.0008049327,0.00005715001,0.001035623,0.9689502,0.00006513877,0.01048272,0.00001830932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811391,0.01090425,0.001045423,0.0002355188,0.0002336719,0.0001323855,0.0005088337,0.0001427908,0.005657974],"genre_scores_gemma":[0.9889289,0.004811497,0.002253414,0.0001420017,0.00006642075,0.00009612551,0.0006887057,0.00001348931,0.002999471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906467,"threshold_uncertainty_score":0.006377697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005566890296630092,"score_gpt":0.223860886322396,"score_spread":0.2182939960257659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}