{"id":"W2114146849","doi":"10.1128/aac.49.11.4536-4545.2005","title":"Pharmacokinetics, Safety, and Tolerability of Caspofungin in Children and Adolescents","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"Georgetown Hospital","funders":"Merck","keywords":"Caspofungin; Regimen; Pharmacokinetics; Tolerability; Dosing; Medicine; Neutropenia; Adverse effect; Area under the curve; Body surface area; Internal medicine; Toxicity; Pharmacology; Gastroenterology; Antifungal; Voriconazole","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496661,0.0001493802,0.0002985121,0.0001115758,0.0001284011,0.0003211765,0.00007610741,0.0001782077,0.0004585143],"category_scores_gemma":[0.0009493098,0.0001138989,0.000203285,0.0001500483,0.0002027889,0.0001772187,0.0001021426,0.0004604819,0.0001327967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003742572,"about_ca_system_score_gemma":0.0003304642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001422646,"about_ca_topic_score_gemma":0.001240435,"domain_scores_codex":[0.99986,0.00003559565,0.00001170228,0.00002145994,0.00004084808,0.00003031244],"domain_scores_gemma":[0.9994741,0.0001224931,0.0002015726,0.00001573202,0.00006454978,0.000121495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.005683284,0.0003448105,0.9255363,0.00009554441,0.00009327507,0.00100916,0.0005105092,0.0008169413,0.02075348,0.0001758764,0.001001896,0.04397885],"study_design_scores_gemma":[0.0001880057,0.007304135,0.9817309,0.0000326642,0.0001026398,0.002081791,0.0003708203,0.0005709516,0.004912422,0.00007238745,0.002622374,0.00001080793],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988641,0.0006762948,0.00007098722,0.00003380851,0.000002871874,0.000005650681,0.00007900525,0.000003125195,0.0002641996],"genre_scores_gemma":[0.9989637,0.0005012839,0.0001332873,0.00005932135,0.000007687972,0.00001449313,0.000175265,0.000002700514,0.0001421342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422646,"threshold_uncertainty_score":0.002828717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006843523792836222,"score_gpt":0.2608551712062994,"score_spread":0.2540116474134632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}