{"id":"W2114146849","doi":"10.1128/aac.49.11.4536-4545.2005","title":"Pharmacokinetics, Safety, and Tolerability of Caspofungin in Children and Adolescents","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"Georgetown Hospital","funders":"Merck","keywords":"Caspofungin; Regimen; Pharmacokinetics; Tolerability; Dosing; Medicine; Neutropenia; Adverse effect; Area under the curve; Body surface area; Internal medicine; Toxicity; Pharmacology; Gastroenterology; Antifungal; Voriconazole","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493653,0.0001361848,0.0003306054,0.00004766792,0.00003483854,0.00001032992,0.00003612158,0.00007005923,0.00006771245],"category_scores_gemma":[0.000008161344,0.0001181399,0.00003436849,0.00006958344,0.0001770168,0.00005820537,0.00003072013,0.0001120693,9.280915e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001911926,"about_ca_system_score_gemma":0.00001763745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001134691,"about_ca_topic_score_gemma":0.00004623712,"domain_scores_codex":[0.9991516,0.00002162252,0.0002833901,0.0002837306,0.00008542635,0.0001742386],"domain_scores_gemma":[0.9996907,0.000009504512,0.00005436589,0.0001292416,0.00003010562,0.00008609433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006637154,0.0002665956,0.9492977,0.0001096237,0.00002913532,0.000001812286,0.000257605,6.473218e-7,0.01227977,0.00000586907,0.0005730336,0.03651448],"study_design_scores_gemma":[0.003538048,0.0000694238,0.9873622,0.0001414837,0.00002405404,0.00002184301,0.00001592204,0.0000763158,0.00734337,0.00000866357,0.001292841,0.0001058339],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997579,0.0002591984,0.00001780976,0.00168093,0.00001607775,0.0003297233,0.00002580951,0.000009478566,0.00008198074],"genre_scores_gemma":[0.9905908,0.006485248,0.0002402004,0.002498535,0.0000524972,5.57051e-7,0.00001041352,0.00001211793,0.0001096925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03806448,"threshold_uncertainty_score":0.4817604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006843523792836222,"score_gpt":0.2608551712062994,"score_spread":0.2540116474134632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}