{"id":"W2114164056","doi":"10.1158/0008-5472.can-04-0866","title":"Blocking the Raf/MEK/ERK Pathway Sensitizes Acute Myelogenous Leukemia Cells to Lovastatin-Induced Apoptosis","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"University of Pennsylvania","keywords":"MAPK/ERK pathway; MEK inhibitor; Lovastatin; Signal transduction; Kinase; Cancer research; Apoptosis; Statin; Protein kinase A; ASK1; Cell biology; MAP kinase kinase kinase; Chemistry; Biology; Mitogen-activated protein kinase kinase; Medicine; Endocrinology; Internal medicine; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007671081,0.0002340101,0.0002514564,0.0001162992,0.0004541851,0.0001143007,0.0005234213,0.0001774892,0.0000452657],"category_scores_gemma":[0.00008765386,0.0001847002,0.0001455183,0.0004549246,0.0001757569,0.000006261752,0.0003524376,0.0004629097,0.00008505373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003112288,"about_ca_system_score_gemma":0.001651682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002142605,"about_ca_topic_score_gemma":0.0008479546,"domain_scores_codex":[0.9974532,0.0001875141,0.0002502847,0.0006388405,0.0005589232,0.0009112172],"domain_scores_gemma":[0.9984715,0.0000463584,0.00005589077,0.0007553094,0.0004022833,0.0002686456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001769469,0.00002233027,0.00001161506,0.00001895842,0.0001203498,0.000001199533,0.0007684638,0.0007354286,0.9655621,0.00006742318,0.01974753,0.01276765],"study_design_scores_gemma":[0.0006198796,0.0001565,0.00009971274,0.00003072696,0.00001987202,0.000008732313,0.0003426308,0.000002273126,0.7547733,0.00006229775,0.2436901,0.0001939212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991921,0.001367271,0.0002496496,0.001594376,0.003340428,0.0006466279,0.0001061412,0.00002385528,0.000750667],"genre_scores_gemma":[0.9822661,0.001807662,0.0003510475,0.001183738,0.01188456,0.0002820523,0.00003216067,0.00007025645,0.002122477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2239426,"threshold_uncertainty_score":0.7531855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03698977345083481,"score_gpt":0.33853956165412,"score_spread":0.3015497882032852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}