{"id":"W2114169525","doi":"10.1128/mcb.20.12.4420-4427.2000","title":"Replication Delay along FRA7H, a Common Fragile Site on Human Chromosome 7, Leads to Chromosomal Instability","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Aphidicolin; Chromosomal fragile site; Biology; Replication timing; DNA replication; Metaphase; Genetics; Chromosome instability; Pre-replication complex; Genome instability; Control of chromosome duplication; Origin recognition complex; Chromosome; Molecular biology; Eukaryotic DNA replication; DNA; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001603196,0.0002749547,0.0002335129,0.00005909401,0.0001891514,0.00002628512,0.000228748,0.000253394,0.0001467952],"category_scores_gemma":[0.00002243766,0.0002783133,0.00009667071,0.0001265976,0.000138578,0.000002976012,0.0001114098,0.0001380852,0.00007231371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001791908,"about_ca_system_score_gemma":0.00003011659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006796372,"about_ca_topic_score_gemma":0.0000645774,"domain_scores_codex":[0.9981237,0.000144938,0.0003021077,0.0009497405,0.0001037282,0.0003758085],"domain_scores_gemma":[0.9988857,0.000006948706,0.00005141342,0.0008445836,0.00003642946,0.0001749322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006865741,0.0001245232,0.009897591,0.00001088386,0.00002354293,0.00001384741,0.00006619878,0.00008087081,0.9835821,0.0001511004,0.0001289568,0.005851731],"study_design_scores_gemma":[0.0006416166,0.001454052,0.02256712,0.00001086458,0.00001848596,0.00002431739,0.00001367689,0.00003700597,0.9357667,0.000226012,0.03879734,0.000442807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960988,0.0005461299,0.0003710802,0.0002298572,0.00005501967,0.0003843287,0.00004258089,0.00002470253,0.002247513],"genre_scores_gemma":[0.9966064,0.00006511516,0.0001941525,0.001876865,0.00003298364,0.0000649142,0.0009016245,0.00003766582,0.0002202998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0478154,"threshold_uncertainty_score":0.9999669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009413394621362647,"score_gpt":0.2511203630641192,"score_spread":0.2417069684427565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}