{"id":"W2114202686","doi":"10.1210/me.2002-0294","title":"Cellular Context of Coregulator and Adaptor Proteins Regulates Human Adenovirus 5 Early Region 1A-Dependent Gene Activation by the Thyroid Hormone Receptor","year":2003,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université Laval; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Western University; Hôtel-Dieu de Québec","funders":"","keywords":"Coactivator; Nuclear receptor coactivator 3; Biology; Corepressor; Nuclear receptor coactivator 1; Nuclear receptor coactivator 2; Thyroid hormone receptor; Cell biology; Nuclear receptor; YY1; Repressor; Gene expression; Receptor; Transcription factor; Gene; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219584,0.0002729232,0.0001406345,0.0001487032,0.0001829263,0.0003749142,0.0001643216,0.0001458202,0.001388537],"category_scores_gemma":[0.0001166179,0.0001608931,0.0001928741,0.00009591107,0.0001924479,0.0001379207,0.0003092887,0.0003285395,0.0006737255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005772306,"about_ca_system_score_gemma":0.0002609357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008771623,"about_ca_topic_score_gemma":0.002065344,"domain_scores_codex":[0.9998515,0.00002838358,0.00001477633,0.00003813419,0.00002837108,0.00003885974],"domain_scores_gemma":[0.9999046,0.00001610211,0.00002877292,0.00001209045,0.000008685012,0.0000297581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009702819,0.00002266204,0.0002279461,0.00001932792,0.000003494436,0.00002458731,0.00001302689,0.00003670163,0.9989069,0.0001375573,0.00002321339,0.0004875549],"study_design_scores_gemma":[0.0000192327,0.0001742642,0.01080701,0.00001164168,0.00001962843,0.0001808541,0.00006883662,0.001422169,0.9834135,0.00009471717,0.003782678,0.000005405231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960283,0.001478749,0.0008290973,0.00005769843,0.00002814701,0.000008690067,0.0002140092,0.00003517371,0.001320208],"genre_scores_gemma":[0.9965578,0.0004770743,0.000823813,0.00003372898,0.000006981788,0.00001336683,0.0005616979,0.00001582384,0.001509719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001388537,"threshold_uncertainty_score":0.004645169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471478560597356,"score_gpt":0.2467089232920275,"score_spread":0.2319941376860539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}