{"id":"W2114219301","doi":"10.4049/jimmunol.1300521","title":"Complete TCR-α Gene Locus Control Region Activity in T Cells Derived In Vitro from Embryonic Stem Cells","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute on Minority Health and Health Disparities; Canadian Institutes of Health Research","keywords":"Biology; T-cell receptor; Transgene; Embryonic stem cell; Gene; Locus control region; Locus (genetics); Reporter gene; Stem cell; T cell; Cellular differentiation; Genetics; Molecular biology; Gene expression; Cell biology; Promoter; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003659051,0.0003464658,0.0002962078,0.0003210828,0.000122992,0.0005087618,0.000234536,0.0001949956,0.0008771247],"category_scores_gemma":[0.0002493117,0.00021061,0.0002451857,0.0002426635,0.0002458256,0.0002034083,0.0002236553,0.0007826124,0.000853427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569646,"about_ca_system_score_gemma":0.0002840637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003292607,"about_ca_topic_score_gemma":0.0004824435,"domain_scores_codex":[0.9995862,0.00008780122,0.00006814836,0.00006933194,0.0001423644,0.00004619348],"domain_scores_gemma":[0.9997216,0.00007891751,0.00005155959,0.00007741251,0.00003654428,0.00003386924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003167415,0.00001236684,0.00008174057,0.00002168508,0.000002912167,0.00002622408,0.00001419267,0.00009166068,0.9987664,0.0001112898,0.00001992044,0.0008199741],"study_design_scores_gemma":[0.00001378821,0.000116973,0.0005162045,0.000005920263,0.00001364667,0.0001365188,0.000007209286,0.0005399295,0.9964585,0.00004161695,0.002147903,0.000001884815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.92115,0.003175219,0.06693779,0.0001355391,0.00009114753,0.0002505411,0.00190185,0.0005339082,0.005823942],"genre_scores_gemma":[0.9696482,0.001986041,0.01757529,0.00007039977,0.00002857892,0.0001858284,0.00475097,0.00012834,0.005626248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008771247,"threshold_uncertainty_score":0.002934217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02844067108461005,"score_gpt":0.264324315485082,"score_spread":0.235883644400472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}