{"id":"W2114229890","doi":"10.1124/dmd.105.006528","title":"MODULATION OF CYP1A2 AND CYP3A6 CATALYTIC ACTIVITIES BY SERUM FROM RABBITS WITH A TURPENTINE-INDUCED INFLAMMATORY REACTION AND INTERLEUKIN 6","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Pyrrolidine dithiocarbamate; CYP1A2; Nitric oxide; Nitric oxide synthase; Chemistry; Biochemistry; Janus kinase; Pharmacology; Kinase; Molecular biology; Endocrinology; Biology; Cytochrome P450; Enzyme; Signal transduction; NF-κB","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003196573,0.0002637462,0.0003543384,0.0001443823,0.000178745,0.00004009162,0.00006940728,0.0001640635,0.00002870697],"category_scores_gemma":[0.00001345734,0.0002377894,0.00003659621,0.0001046598,0.0001696737,0.0005283498,0.00006918218,0.0003017978,0.000002626262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001710582,"about_ca_system_score_gemma":0.00002714094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001344225,"about_ca_topic_score_gemma":0.00006039916,"domain_scores_codex":[0.998661,0.0002231984,0.000331949,0.0003754497,0.0001642205,0.0002441191],"domain_scores_gemma":[0.9992063,0.0001236768,0.0002810071,0.0001337745,0.00005504354,0.0002001831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006087706,0.0001498466,0.005711853,0.0000656535,0.0001517178,0.000003090084,0.002691546,0.00003880894,0.904951,0.0004328802,0.0001790166,0.08501583],"study_design_scores_gemma":[0.004679026,0.00005004506,0.2524922,0.00005347671,0.0008198839,0.00003360466,0.0005825715,0.007596663,0.7195379,0.0004895591,0.01319791,0.0004671785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923566,0.005977146,0.00007996123,0.0003759851,0.0002631627,0.000338033,0.0002978207,0.00004044931,0.0002708344],"genre_scores_gemma":[0.9971603,0.001758492,0.0001486433,0.0003223945,0.000271027,0.00003365436,0.0001693027,0.00002516374,0.0001110303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2467803,"threshold_uncertainty_score":0.969677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205686829498199,"score_gpt":0.315790857103446,"score_spread":0.2952221741536261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}