{"id":"W2114229890","doi":"10.1124/dmd.105.006528","title":"MODULATION OF CYP1A2 AND CYP3A6 CATALYTIC ACTIVITIES BY SERUM FROM RABBITS WITH A TURPENTINE-INDUCED INFLAMMATORY REACTION AND INTERLEUKIN 6","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Pyrrolidine dithiocarbamate; CYP1A2; Nitric oxide; Nitric oxide synthase; Chemistry; Biochemistry; Janus kinase; Pharmacology; Kinase; Molecular biology; Endocrinology; Biology; Cytochrome P450; Enzyme; Signal transduction; NF-κB","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007467911,0.001000947,0.0007267087,0.000711823,0.0003971209,0.0004538893,0.0002834887,0.0007394475,0.001389908],"category_scores_gemma":[0.00105633,0.0004330364,0.0007311797,0.0003564848,0.0009217124,0.0005011716,0.0002983485,0.001830485,0.0006754549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003479132,"about_ca_system_score_gemma":0.0003161815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005233538,"about_ca_topic_score_gemma":0.0005407041,"domain_scores_codex":[0.9993155,0.0001558281,0.00009219479,0.000112106,0.0001304639,0.0001939414],"domain_scores_gemma":[0.9992125,0.0001702191,0.0002227717,0.0001684577,0.00008126188,0.0001447668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01608673,0.000800883,0.003355386,0.0001080828,0.0000599688,0.0006152831,0.0002171277,0.0001341469,0.9730132,0.0002872557,0.0002143868,0.005107468],"study_design_scores_gemma":[0.0007320339,0.007338678,0.01916357,0.00002115711,0.0001682356,0.001360759,0.0001309033,0.002205244,0.9670156,0.0002294036,0.001608604,0.00002585646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950032,0.001048687,0.002401453,0.0002900772,0.0001549139,0.00006399494,0.0001457362,0.0000805741,0.0008112823],"genre_scores_gemma":[0.9964061,0.0006090777,0.001028167,0.0001824144,0.000136768,0.00009511635,0.0003681295,0.00002273682,0.001151439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001389908,"threshold_uncertainty_score":0.004649758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205686829498199,"score_gpt":0.315790857103446,"score_spread":0.2952221741536261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}