{"id":"W2114231575","doi":"10.1093/toxsci/kfj166","title":"Salicylate Disrupts Interrenal Steroidogenesis and Brain Glucocorticoid Receptor Expression in Rainbow Trout","year":2006,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Internal medicine; Endocrinology; Steroidogenic acute regulatory protein; Cholesterol side-chain cleavage enzyme; Glucocorticoid receptor; Glucocorticoid; Trout; Rainbow trout; Biology; Chemistry; Cytochrome P450; Gene expression; Medicine; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000512463,0.0001301358,0.0001599771,0.00004775678,0.00009800112,0.00004082259,0.0001858706,0.0001439635,0.0001118475],"category_scores_gemma":[0.000425056,0.00008378247,0.0000384943,0.0001426917,0.0006389812,0.00001170446,0.0001388805,0.00006558659,0.00001242073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001511755,"about_ca_system_score_gemma":0.00003074333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001675026,"about_ca_topic_score_gemma":0.00004684455,"domain_scores_codex":[0.9986973,0.0001728781,0.000213,0.0005175315,0.0001097432,0.0002895353],"domain_scores_gemma":[0.9996569,0.00006730157,0.0000729904,0.0001337905,0.00001549727,0.0000535925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008400892,0.00007777224,0.05928816,0.000002514724,0.00000265091,0.000001572338,0.00002339607,0.00002791788,0.937265,0.0001395055,0.0008534302,0.002234028],"study_design_scores_gemma":[0.0005226462,0.001389601,0.4789158,0.00001692043,0.000002888223,0.00001808922,0.000177552,0.00005995217,0.5091141,0.0006823501,0.008872692,0.0002273322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959838,0.000658516,0.0001315151,0.001418079,0.0001254589,0.0001846659,0.000004436702,0.00001019604,0.001483275],"genre_scores_gemma":[0.9977805,0.00006015128,0.0006716507,0.0004446191,0.0001490579,0.00001604326,0.00001062575,0.000003672018,0.0008636703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4281509,"threshold_uncertainty_score":0.341655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013584343059951,"score_gpt":0.2881861838067216,"score_spread":0.2680503403761221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}