{"id":"W2114240336","doi":"10.1093/hmg/ddq060","title":"AP-2α knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Dental and Craniofacial Research; National Eye Institute; National Institutes of Health; Research to Prevent Blindness","keywords":"Biology; Morphogenesis; Optic cup (embryology); Cell biology; Stalk; Knockout mouse; Gene; Genetics; Phenotype; Eye development","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960484,0.00161165,0.0004127747,0.001311261,0.0003424697,0.0006254629,0.0005777855,0.0007900907,0.003814131],"category_scores_gemma":[0.0002101785,0.0005608548,0.0004105555,0.0004329281,0.0009829365,0.0004141202,0.0005345797,0.001267132,0.001447238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004014818,"about_ca_system_score_gemma":0.0002639813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006087419,"about_ca_topic_score_gemma":0.0007583452,"domain_scores_codex":[0.9995868,0.00003343553,0.00005975616,0.0001213789,0.0001453439,0.00005339956],"domain_scores_gemma":[0.9992408,0.00004580497,0.0004076724,0.00006367049,0.00002506083,0.0002171876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001359953,0.00002399087,0.0004792693,0.00004391789,0.00001419035,0.0005538643,0.00003030169,0.00007192112,0.9971101,0.0001603357,0.00005236696,0.001323816],"study_design_scores_gemma":[0.0000759469,0.0004007615,0.03741129,0.00004555482,0.00009488104,0.006467296,0.000186493,0.001436714,0.9479767,0.0004385745,0.005439205,0.00002647835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840917,0.001547066,0.008424905,0.0001515618,0.00007700524,0.00004309883,0.001742176,0.0006824366,0.003240176],"genre_scores_gemma":[0.9712865,0.001846286,0.005873826,0.0001027824,0.00004104159,0.0001110769,0.002011776,0.0002475665,0.01847916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003814131,"threshold_uncertainty_score":0.01275957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009633735129256154,"score_gpt":0.2412297180388513,"score_spread":0.2315959829095952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}