{"id":"W2114240336","doi":"10.1093/hmg/ddq060","title":"AP-2α knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Dental and Craniofacial Research; National Eye Institute; National Institutes of Health; Research to Prevent Blindness","keywords":"Biology; Morphogenesis; Optic cup (embryology); Cell biology; Stalk; Knockout mouse; Gene; Genetics; Phenotype; Eye development","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002314169,0.0003700008,0.0003452115,0.0001056688,0.0001713754,0.00004516113,0.0003199375,0.0003070932,0.00002558531],"category_scores_gemma":[0.0001439493,0.0003971619,0.0001581068,0.0001095524,0.000336737,0.000003721243,0.0003896061,0.0002472186,0.00000936163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001009294,"about_ca_system_score_gemma":0.00006714999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001468824,"about_ca_topic_score_gemma":0.00007812723,"domain_scores_codex":[0.9981592,0.0001021929,0.0003999245,0.0006317804,0.0002664158,0.0004405143],"domain_scores_gemma":[0.9987389,0.00003071883,0.0001880225,0.0006704337,0.0002022927,0.0001696059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001195428,0.00005657418,0.004526648,0.0001040109,0.0001278816,0.00005093856,0.0002258085,0.0002334779,0.9941419,0.00008574272,0.00009715863,0.0003379221],"study_design_scores_gemma":[0.0006519348,0.0003693311,0.007461075,0.00004204271,0.0001510648,0.00007441791,0.0001799884,0.00008935374,0.9891016,0.00008554279,0.00132477,0.0004688858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942938,0.003377192,0.001621275,0.00002951293,0.0001181007,0.0002916222,0.00003001135,0.00002390542,0.0002145654],"genre_scores_gemma":[0.9899259,0.00008266538,0.009451529,0.0001048303,0.0001433622,0.00002782128,0.00007301739,0.00008969047,0.0001012007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007830254,"threshold_uncertainty_score":0.999848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009633735129256154,"score_gpt":0.2412297180388513,"score_spread":0.2315959829095952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}