{"id":"W2114248978","doi":"10.1073/pnas.97.7.3207","title":"Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells","year":2000,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":433,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"PTEN; Protein kinase B; Integrin-linked kinase; LNCaP; Cancer research; PI3K/AKT/mTOR pathway; Tensin; Kinase; Transfection; Phosphorylation; Biology; Cell cycle; Chemistry; Tumor suppressor gene; Molecular biology; Cell biology; Protein kinase A; Signal transduction; Apoptosis; Cancer cell; Cell culture; Cyclin-dependent kinase 2; Biochemistry; Cancer; Carcinogenesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004472455,0.0001054831,0.0001715528,0.00009140942,0.00005885687,0.000009609622,0.0002171639,0.0001133967,0.00001268795],"category_scores_gemma":[0.0001295959,0.00007904956,0.00003963484,0.0002842509,0.0008472359,0.00005358009,0.00008183973,0.00009378415,4.454308e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001305595,"about_ca_system_score_gemma":0.00006592514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006640863,"about_ca_topic_score_gemma":3.815754e-7,"domain_scores_codex":[0.9988049,0.00001132276,0.0003592212,0.0002480162,0.0004677871,0.0001087998],"domain_scores_gemma":[0.999,0.00003163065,0.0005833542,0.00001628202,0.0003397543,0.0000290244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001219539,0.00008580618,0.0009445955,0.0003391809,0.00001451872,2.814165e-9,0.000240161,0.0002527577,0.9969334,0.000127821,0.00002902124,0.0009107738],"study_design_scores_gemma":[0.0003066606,0.0001870849,0.002684913,0.0003534643,0.00001562838,4.662196e-7,0.0001738781,0.0001457894,0.9944748,0.00154475,0.00003247749,0.00008011778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985684,0.0003809515,6.601793e-7,0.0003103115,0.00001198502,0.0002995588,0.00008518853,0.000002271976,0.0003406616],"genre_scores_gemma":[0.9991047,0.0003238368,0.0004395848,0.00003032809,0.00003757484,0.00002668668,0.00000115459,0.000005477824,0.00003060268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002458637,"threshold_uncertainty_score":0.3223548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684582681743316,"score_gpt":0.2690635277541983,"score_spread":0.2522177009367651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}