{"id":"W2114262219","doi":"10.1038/emboj.2009.399","title":"The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1","year":2010,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"IQGAP1; Signal transducing adaptor protein; GRB2; Cell biology; Phosphotyrosine-binding domain; Cytoskeleton; Biology; Scaffold protein; Receptor; Signal transduction; SH2 domain; Biochemistry; Proto-oncogene tyrosine-protein kinase Src; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001185278,0.00009939884,0.00008171996,0.00002019287,0.0005770525,0.00006874515,0.000390558,0.00006689873,0.00006669618],"category_scores_gemma":[0.0002087221,0.00004624336,0.0001080955,0.00009356947,0.0001344747,0.000005329781,0.00007987667,0.0002672154,0.00001022726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009181665,"about_ca_system_score_gemma":0.00008850197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005503992,"about_ca_topic_score_gemma":0.00002488767,"domain_scores_codex":[0.9991248,0.0001249011,0.0002332259,0.0001083251,0.0002312641,0.0001774669],"domain_scores_gemma":[0.9991875,0.00004629453,0.0001938489,0.0003645718,0.0001381419,0.00006970211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008671893,0.00001211818,0.00006485813,0.000002128026,0.00003511132,2.07852e-7,0.0001105375,0.0001043587,0.9881616,0.001546058,0.004314221,0.005562048],"study_design_scores_gemma":[0.0002432325,0.00007771,0.001569609,0.00001664709,0.00001046201,0.00005224294,0.0002303885,0.00005860777,0.7470813,0.001275542,0.2492981,0.00008615516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881422,0.0002320035,0.00276383,0.008019741,0.0003332982,0.0002076337,0.000005535989,0.000004612257,0.0002911823],"genre_scores_gemma":[0.9975531,0.00005666087,0.0005792715,0.0002956721,0.001127645,0.00001112392,0.000007071223,0.00001390439,0.000355568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2449838,"threshold_uncertainty_score":0.4438279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006327132539730254,"score_gpt":0.2397208379650784,"score_spread":0.2333937054253481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}