{"id":"W2114262219","doi":"10.1038/emboj.2009.399","title":"The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1","year":2010,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"IQGAP1; Signal transducing adaptor protein; GRB2; Cell biology; Phosphotyrosine-binding domain; Cytoskeleton; Biology; Scaffold protein; Receptor; Signal transduction; SH2 domain; Biochemistry; Proto-oncogene tyrosine-protein kinase Src; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657237,0.0003111897,0.0002262149,0.0002337682,0.0004268725,0.0006731087,0.0004437224,0.0005669946,0.003748551],"category_scores_gemma":[0.0003612264,0.0002301782,0.0002556103,0.0002318345,0.0004771504,0.0007030342,0.0006997315,0.0009848732,0.002107456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008121344,"about_ca_system_score_gemma":0.0002912712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009546084,"about_ca_topic_score_gemma":0.0008641779,"domain_scores_codex":[0.9998685,0.00001523497,0.000006742848,0.00003782217,0.00002850043,0.00004308409],"domain_scores_gemma":[0.9998927,0.00001909958,0.00002328022,0.00001633239,0.00001233071,0.00003635867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001771091,0.00001483925,0.0003010757,0.00002940445,0.000004507736,0.0001321313,0.00001579912,0.0001071314,0.9962342,0.001150032,0.000336432,0.001497342],"study_design_scores_gemma":[0.00007400343,0.00005936212,0.00915402,0.000009334392,0.00001031105,0.0006875431,0.00007435787,0.004727486,0.9767506,0.0008869261,0.007551555,0.00001440509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839008,0.001408126,0.006828084,0.0008394118,0.0001226361,0.00003205928,0.0004901328,0.000217596,0.006161069],"genre_scores_gemma":[0.9948113,0.0003764975,0.001397784,0.0001472221,0.00002520545,0.00002228828,0.000538666,0.00004887336,0.002632144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003748551,"threshold_uncertainty_score":0.01254022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006327132539730254,"score_gpt":0.2397208379650784,"score_spread":0.2333937054253481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}