{"id":"W2114265257","doi":"10.1016/j.archoralbio.2015.02.021","title":"Green tea polyphenol epigallocatechin-3-gallate and cranberry proanthocyanidins act in synergy with cathelicidin (LL-37) to reduce the LPS-induced inflammatory response in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts","year":2015,"lang":"en","type":"article","venue":"Archives of Oral Biology","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Secretion; Aggregatibacter actinomycetemcomitans; Cathelicidin; Chemokine; Chemistry; Pharmacology; Cytokine; Lipopolysaccharide; Matrix metalloproteinase; Interleukin 8; Immunology; Biology; Biochemistry; Innate immune system; Medicine; Internal medicine; Porphyromonas gingivalis; Receptor; Periodontitis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006841476,0.0002536206,0.0005081916,0.0002687454,0.00007519359,0.00001224479,0.0003513286,0.000224312,0.000008072556],"category_scores_gemma":[0.0001398903,0.0001652675,0.00004921271,0.000175212,0.0008586924,0.00008396839,0.0003469473,0.0004490019,0.000006549251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002420092,"about_ca_system_score_gemma":0.0002906592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002227798,"about_ca_topic_score_gemma":0.006725665,"domain_scores_codex":[0.9978514,0.0007062199,0.0004344474,0.0004596961,0.0001149234,0.0004333674],"domain_scores_gemma":[0.9990353,0.0003274355,0.0001437013,0.0003016227,0.00004811663,0.0001438468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01218088,0.00008005399,0.03567164,0.00004005841,0.00004750448,0.00003977948,0.002539253,0.0006328455,0.9470398,0.0002301857,0.0000254433,0.001472576],"study_design_scores_gemma":[0.005530754,0.004094674,0.2733819,0.0003734647,0.00002573269,0.0002874129,0.0003884397,0.005105148,0.7063543,0.003592592,0.000249504,0.0006161204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983664,0.000209444,0.00003033095,0.0004935019,0.00004280973,0.0005178261,0.0002436457,0.00001441404,0.0000815831],"genre_scores_gemma":[0.9984272,0.00002246554,0.001229903,0.00004839932,0.00001940431,0.00002335712,0.00001688074,0.00002152976,0.0001908648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2406855,"threshold_uncertainty_score":0.6739412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02699646833563263,"score_gpt":0.2905960121051782,"score_spread":0.2635995437695455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}