{"id":"W2114295161","doi":"10.1093/aje/kwp119","title":"Genome-Wide Association Studies, Field Synopses, and the Development of the Knowledge Base on Genetic Variation and Human Diseases","year":2009,"lang":"en","type":"article","venue":"American Journal of Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; U.S. Department of Health and Human Services; Office of Genomics and Precision Public Health; Erasmus Universitair Medisch Centrum Rotterdam; National Center for Chronic Disease Prevention and Health Promotion; British Heart Foundation; U.S. National Library of Medicine; Medical Research Council; University of Ioannina; University of North Carolina at Chapel Hill; European Commission; National Institutes of Health; University of Leicester; Genome Canada; McGill University; University of Ottawa; Imperial College London; University of Washington; National Cancer Institute; National Center for Research Resources; Centers for Disease Control and Prevention; University of Pennsylvania; Massachusetts General Hospital; Tufts Medical Center","keywords":"Genome-wide association study; Genetic association; Human genome; Genetic epidemiology; Multidisciplinary approach; Data science; Genetics; Biology; Bioinformatics; Genome; Computer science; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1181252,0.001588104,0.002407907,0.01592454,0.003455937,0.01435316,0.00232977,0.003320063,0.007876606],"category_scores_gemma":[0.1142053,0.001131902,0.001426386,0.01122868,0.01072183,0.01626479,0.01154186,0.009422483,0.002490071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004583388,"about_ca_system_score_gemma":0.01057138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002189593,"about_ca_topic_score_gemma":0.003091983,"domain_scores_codex":[0.9532762,0.02610846,0.008370936,0.003431666,0.007810264,0.001002657],"domain_scores_gemma":[0.7729666,0.1115889,0.02579815,0.03025585,0.04349969,0.01589084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003630607,0.0001354398,0.005582497,0.004293081,0.0003897673,0.0003321111,0.004227279,0.0008453795,0.002284025,0.1108814,0.3854588,0.4852071],"study_design_scores_gemma":[0.00008756178,0.0001780797,0.007505687,0.003351492,0.0001167209,0.0004671447,0.003394764,0.0004345033,0.0005751211,0.1266231,0.8571488,0.000117161],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.008808124,0.3028447,0.08480032,0.4615123,0.1123527,0.001084848,0.002203609,0.001168127,0.02522509],"genre_scores_gemma":[0.1076715,0.3117884,0.2201526,0.1624022,0.1613523,0.003132163,0.006486264,0.001327122,0.02568752],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.1181252,"threshold_uncertainty_score":0.6247134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01896025028107673,"score_gpt":0.3065379919048395,"score_spread":0.2875777416237628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}