{"id":"W2114307219","doi":"10.1096/fj.04-1994fje","title":"Degradation of BACE by the ubiquitin‐proteasome pathway","year":2004,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Lactacystin; Proteasome; Ubiquitin; Chemistry; Protein degradation; Amyloid precursor protein secretase; Amyloid precursor protein; Protease; Cell biology; Proteolysis; Alpha secretase; Proteasome inhibitor; Biochemistry; Enzyme; Biology; Alzheimer's disease; Gene; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003686136,0.00008544891,0.0001186115,0.00003239225,0.0002360476,0.00002674578,0.0001411708,0.00002657432,0.000167997],"category_scores_gemma":[0.00006296989,0.00003798293,0.0001056618,0.0001161626,0.0001280337,0.00007777198,0.00002471174,0.0002706742,0.00006217449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008310682,"about_ca_system_score_gemma":0.0003043177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000535485,"about_ca_topic_score_gemma":0.000003010208,"domain_scores_codex":[0.9989795,0.00009143142,0.0001700044,0.00007333094,0.0004702206,0.0002155168],"domain_scores_gemma":[0.9993365,0.00005333858,0.0001104528,0.0002113362,0.0001069913,0.0001813541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005485496,0.006067804,0.04574253,0.0002292652,0.02809981,0.001627836,0.00367919,0.0002576885,0.7753602,0.006303671,0.02090031,0.1062462],"study_design_scores_gemma":[0.007372595,0.001191452,0.01504804,0.0002959077,0.000730111,0.001985882,0.001284037,0.00004148473,0.966273,0.004778269,0.0008454463,0.0001537865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880952,0.005538317,0.0002289156,0.004638251,0.00004648305,0.000321599,0.00003003898,0.0000102847,0.001090909],"genre_scores_gemma":[0.9990707,0.0002181032,0.00009415576,0.0001757634,0.0001212745,0.000009578154,0.00001571503,0.00001083444,0.000283858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1909128,"threshold_uncertainty_score":0.183945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756048266338623,"score_gpt":0.290691665806363,"score_spread":0.2631311831429767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}