{"id":"W2114322809","doi":"10.1093/nar/30.5.1132","title":"The contribution of 2'-hydroxyls to the cleavage activity of the Neurospora VS ribozyme","year":2002,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Government of Ontario","keywords":"Ribozyme; VS ribozyme; Hairpin ribozyme; Mammalian CPEB3 ribozyme; Biology; Cleavage (geology); Stereochemistry; Stem-loop; Nucleotide; Genetics; Biophysics; Biochemistry; RNA; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002546813,0.0002788529,0.0002522493,0.0001469704,0.0001404493,0.0004020668,0.0001385404,0.0002187635,0.0004775294],"category_scores_gemma":[0.0003648046,0.0001477819,0.0002142701,0.00009784025,0.0002839118,0.0001674575,0.0001703623,0.0002890085,0.0001290183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000256204,"about_ca_system_score_gemma":0.0001746862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004980348,"about_ca_topic_score_gemma":0.0006664923,"domain_scores_codex":[0.9997899,0.00005024239,0.0000180378,0.0000424319,0.0000595843,0.00003980888],"domain_scores_gemma":[0.9996965,0.0001059869,0.00006277263,0.00004064719,0.00002745777,0.0000667018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001142489,0.000007552367,0.001097734,0.00001857883,0.000004516784,0.00004709933,0.00001322265,0.000185592,0.9963012,0.00007555771,0.000005139561,0.002129567],"study_design_scores_gemma":[0.00001551414,0.0002703736,0.01158302,0.000003983827,0.00002288212,0.0002601083,0.00002717881,0.0008915814,0.9859219,0.0001420106,0.0008544855,0.000006984604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977342,0.0007577006,0.0009612461,0.00002319238,0.000006257952,0.000004181444,0.000038088,0.000009130361,0.0004660527],"genre_scores_gemma":[0.9981804,0.0003748933,0.0009681109,0.0000226826,0.000006682545,0.000003952181,0.00009149374,0.000006190378,0.0003457239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004980348,"threshold_uncertainty_score":0.00185895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03124552812163859,"score_gpt":0.2989018507301341,"score_spread":0.2676563226084955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}