{"id":"W2114329647","doi":"10.1073/pnas.0902919106","title":"Ablation of triadin causes loss of cardiac Ca <sup>2+</sup> release units, impaired excitation–contraction coupling, and cardiac arrhythmias","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institutes of Health; American Heart Association","keywords":"Calsequestrin; Ryanodine receptor; Endoplasmic reticulum; Ryanodine receptor 2; Chemistry; Internal medicine; Biophysics; Myocyte; Cardiac muscle; Endocrinology; Calcium; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001122709,0.0001276123,0.0004797431,0.0002527847,0.0001352776,0.000006881548,0.0001199956,0.0001514131,0.000005017341],"category_scores_gemma":[0.001249038,0.00009514219,0.0001657329,0.000898154,0.0007162438,0.0003739076,0.00002523649,0.0002065791,3.8474e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004845409,"about_ca_system_score_gemma":0.0001227783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001899637,"about_ca_topic_score_gemma":1.85643e-8,"domain_scores_codex":[0.9982889,0.00001772408,0.0005180226,0.0002405576,0.0007743294,0.0001605114],"domain_scores_gemma":[0.9981337,0.0002785206,0.0006719348,0.00001895442,0.0008422434,0.0000546357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001142541,0.000154726,0.02257098,0.0004503297,0.0003356566,1.986328e-7,0.002033905,0.0060688,0.9270647,0.0358352,0.001296919,0.003046043],"study_design_scores_gemma":[0.00105866,0.0007169241,0.6515334,0.0004273357,0.0003428818,0.00003832982,0.00103133,0.007956645,0.3195829,0.01693204,0.0001806957,0.0001988157],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963697,0.001084119,0.00000109732,0.001423493,0.00002687138,0.0003618707,0.00004800992,0.00001094445,0.0006738552],"genre_scores_gemma":[0.9988891,0.0005052569,0.0002218655,0.00008311719,0.0002054307,0.000007071115,0.000002550083,0.000004839761,0.0000807703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6289624,"threshold_uncertainty_score":0.3879786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02449902680607696,"score_gpt":0.2907442610612372,"score_spread":0.2662452342551602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}