{"id":"W2114379471","doi":"10.1074/jbc.m505401200","title":"Consequences of Disease-causing Mutations on Lubricin Protein Synthesis, Secretion, and Post-translational Processing","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute; Arthritis Foundation; National Institute of General Medical Sciences; Burroughs Wellcome Fund","keywords":"Epitope; Proprotein convertase; Nonsense mutation; Molecular biology; Furin; Biology; Chemistry; Biochemistry; Gene; Mutation; Antibody; Missense mutation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001835466,0.0008474221,0.000279606,0.0003039684,0.0001933696,0.0002356109,0.0001791526,0.0005964825,0.001047941],"category_scores_gemma":[0.0005063523,0.0001765158,0.0003688505,0.0001862471,0.0004635531,0.0001558404,0.0003015628,0.0004252163,0.0002377404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002613841,"about_ca_system_score_gemma":0.0001979227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006994645,"about_ca_topic_score_gemma":0.000511186,"domain_scores_codex":[0.9997427,0.00004981511,0.00006064387,0.00005003904,0.00005088296,0.00004591193],"domain_scores_gemma":[0.9996207,0.00009434362,0.0001038783,0.00002925509,0.00002515886,0.0001266357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000275534,0.00003820662,0.002537909,0.00003535591,0.00002159193,0.005124063,0.00005414711,0.0001103015,0.9904906,0.0001281181,0.00004275015,0.00114131],"study_design_scores_gemma":[0.000183474,0.001288275,0.08190655,0.00002044258,0.0001775026,0.05340746,0.0002118628,0.002499552,0.8574885,0.0002853751,0.002501846,0.00002916673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991007,0.0002408807,0.0003166045,0.00002948802,0.00001002136,0.000005150249,0.00008343873,0.000018978,0.0001947748],"genre_scores_gemma":[0.9991232,0.0001302788,0.0003067547,0.00001853985,0.000005694837,0.000003787867,0.0001518227,0.00001479706,0.0002451551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047941,"threshold_uncertainty_score":0.003505707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03869741549039001,"score_gpt":0.3178073016634634,"score_spread":0.2791098861730734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}