{"id":"W2114383393","doi":"10.1158/1535-7163.mct-10-0735","title":"Pancratistatin Selectively Targets Cancer Cell Mitochondria and Reduces Growth of Human Colon Tumor Xenografts","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Windsor","funders":"National Research Council Canada","keywords":"Apoptosis; Programmed cell death; Cancer cell; Biology; Cancer research; Mitochondrion; Cell culture; Molecular biology; Terminal deoxynucleotidyl transferase; Cancer; Cell biology; TUNEL assay; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004640879,0.0002473957,0.0003209937,0.00003308345,0.00008587628,0.00002007853,0.0002111139,0.0001078525,0.0008997045],"category_scores_gemma":[0.000005038209,0.0002329282,0.00008945325,0.0001573302,0.0001579403,0.00005290842,0.00005089263,0.0001645433,0.000001051694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007949081,"about_ca_system_score_gemma":0.00006340949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001829657,"about_ca_topic_score_gemma":0.0001334587,"domain_scores_codex":[0.9987925,0.00003031234,0.0002970746,0.0003592398,0.0002119402,0.0003089636],"domain_scores_gemma":[0.9993333,0.00002940172,0.0002160345,0.00019207,0.0001336331,0.0000955706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006579766,0.0001461635,0.002292725,0.0001565224,0.0001609949,0.000009624639,0.0007919672,4.101022e-7,0.9943015,0.0001389771,0.0001722792,0.001763035],"study_design_scores_gemma":[0.0004839827,0.00005712074,0.0006912018,0.00008283804,0.0001521202,0.000001622071,0.0001094507,0.0000232464,0.9964066,0.0007105187,0.0009965214,0.0002848317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831803,0.01048753,0.00006014667,0.00005537596,0.00007086455,0.0001069897,0.0001029979,0.00003882525,0.005896913],"genre_scores_gemma":[0.9973184,0.001061055,0.0009250526,0.0002685824,0.00008194824,0.0001111747,0.000008122312,0.00005342961,0.000172179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0141381,"threshold_uncertainty_score":0.9851134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02270471345677224,"score_gpt":0.2597427636189568,"score_spread":0.2370380501621846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}