{"id":"W2114409750","doi":"10.1128/mmbr.00045-10","title":"Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease","year":2011,"lang":"en","type":"review","venue":"Microbiology and Molecular Biology Reviews","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":569,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cryptococcus neoformans; Candida albicans; Aspergillus fumigatus; Antifungal drug; Virulence; Signal transduction; Drug resistance; Efflux; Corpus albicans; Morphogenesis; Microbiology; Cryptococcosis; Virulence factor; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003345767,0.0004088329,0.0004816628,0.0004849519,0.0003419216,0.00168468,0.0004881251,0.0006507734,0.00199615],"category_scores_gemma":[0.000375863,0.0002382162,0.0003612994,0.0003831533,0.0007062064,0.0008279434,0.0006686657,0.0007317673,0.001134887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00064453,"about_ca_system_score_gemma":0.0007646853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005531439,"about_ca_topic_score_gemma":0.0005076458,"domain_scores_codex":[0.9996637,0.00005054326,0.00002632983,0.00009159397,0.00009167289,0.00007622466],"domain_scores_gemma":[0.9998159,0.00003166114,0.00005067186,0.00001238217,0.00005307869,0.00003638223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004502239,0.00006096436,0.00434257,0.003571154,0.0001197907,0.001585562,0.0006183924,0.00250851,0.6740289,0.06392681,0.01044671,0.2383405],"study_design_scores_gemma":[0.00008105924,0.0007141483,0.04212497,0.001490036,0.0002747735,0.003334723,0.001050554,0.005239121,0.1956145,0.03575629,0.7141852,0.0001347011],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.20948,0.6175256,0.06540393,0.006961564,0.002430263,0.0002566227,0.002186894,0.001898006,0.09385705],"genre_scores_gemma":[0.5844491,0.377621,0.01308142,0.002124788,0.0006702668,0.0001997212,0.002124223,0.0001320829,0.01959733],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00199615,"threshold_uncertainty_score":0.006677806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03458673767475633,"score_gpt":0.3152856116947256,"score_spread":0.2806988740199693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}