{"id":"W2114410821","doi":"10.1105/tpc.015842","title":"A Gain-of-Function Mutation in a Plant Disease Resistance Gene Leads to Constitutive Activation of Downstream Signal Transduction Pathways in <i>suppressor of npr1-1</i> , <i>constitutive 1</i>","year":2003,"lang":"en","type":"article","venue":"The Plant Cell","topic":"Plant-Microbe Interactions and Immunity","field":"Agricultural and Biological Sciences","cited_by":490,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Österreichischen Akademie der Wissenschaften; National Science Foundation","keywords":"Biology; Genetics; Gene; Pseudomonas syringae; Point mutation; Mutant; Arabidopsis; NPR1; Mutation; R gene; Plant disease resistance; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001143592,0.0006384127,0.0001681585,0.0002792738,0.0002056885,0.0002431373,0.000412771,0.000438655,0.001871755],"category_scores_gemma":[0.0001190541,0.0001860916,0.0002884667,0.0001405133,0.0003081048,0.0001223713,0.0002356285,0.0007756726,0.0008893344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004477651,"about_ca_system_score_gemma":0.0002476821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008567533,"about_ca_topic_score_gemma":0.001197914,"domain_scores_codex":[0.9998449,0.00002041593,0.0000168158,0.00003936933,0.00005038911,0.00002811099],"domain_scores_gemma":[0.9997795,0.0000504235,0.00005363388,0.00002239795,0.00001319843,0.00008076624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000293946,0.0000222205,0.00006055945,0.0000118155,0.000002056208,0.00009008621,0.000005646099,0.00003201718,0.999397,0.00008178524,0.00002962297,0.0002377925],"study_design_scores_gemma":[0.00005490107,0.0002424484,0.009131792,0.00001833675,0.00002393265,0.001093784,0.00003206696,0.00383246,0.9805177,0.0001029206,0.00493644,0.00001310076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935661,0.0003273168,0.002773701,0.0001088036,0.00005278062,0.00004248559,0.0007309489,0.0002534158,0.002144393],"genre_scores_gemma":[0.9907187,0.0002549925,0.002137393,0.00007003959,0.00001759091,0.0000406751,0.00169856,0.0001098864,0.004952201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001871755,"threshold_uncertainty_score":0.006261706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01936110648488502,"score_gpt":0.195799059280068,"score_spread":0.176437952795183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}