{"id":"W2114430445","doi":"10.1038/ncomms1187","title":"Chromatin remodelling complex dosage modulates transcription factor function in heart development","year":2011,"lang":"en","type":"article","venue":"Nature Communications","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Institute of Genetics; Canadian Institutes of Health Research; National Institutes of Health; National Center for Research Resources; American Heart Association; Circulation Foundation; Lawrence J. and Florence A. DeGeorge Charitable Trust; National Heart, Lung, and Blood Institute; Gladstone Institutes; California Institute for Regenerative Medicine","keywords":"Transcription factor; Haploinsufficiency; Heart development; Chromatin; Biology; TBX1; Zebrafish; Genetics; Chromatin remodeling; Cell biology; Promoter; Gene; Transcription (linguistics); Phenotype; Gene expression; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162831,0.0001021849,0.00009512334,0.00009248085,0.0001507121,0.00001574583,0.0003616676,0.0002347115,0.00005292515],"category_scores_gemma":[0.00003603304,0.0001060813,0.00004811072,0.0001707066,0.000056956,0.000009203592,0.0001433678,0.0004052683,0.00002642813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003775948,"about_ca_system_score_gemma":0.00006590292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003958101,"about_ca_topic_score_gemma":0.001686721,"domain_scores_codex":[0.9991874,0.0001255385,0.0001966226,0.0001958354,0.0001167893,0.0001778486],"domain_scores_gemma":[0.9990066,0.0000199462,0.00002770492,0.0008005695,0.00009331122,0.00005185085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005820453,0.0001771008,0.005139286,0.00001655945,0.00002564227,3.68041e-7,0.0005319529,0.00001454534,0.9870232,0.0002015007,0.0002638686,0.00654781],"study_design_scores_gemma":[0.0008542906,0.0002358039,0.6216561,0.00005855844,0.0000152079,0.0000158962,0.0001822592,0.006334495,0.2075837,0.0002900938,0.1622912,0.0004824131],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926048,0.003234704,0.001368277,0.0002255786,0.00005791419,0.0003311887,0.00001149195,0.0000284136,0.002137615],"genre_scores_gemma":[0.9832228,0.0001595264,0.01600653,0.0001082451,0.00002052997,0.00004200527,0.0002977503,0.00001631558,0.0001262939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7794395,"threshold_uncertainty_score":0.4325869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08250980139244724,"score_gpt":0.3205444382893215,"score_spread":0.2380346368968743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}