{"id":"W2114430445","doi":"10.1038/ncomms1187","title":"Chromatin remodelling complex dosage modulates transcription factor function in heart development","year":2011,"lang":"en","type":"article","venue":"Nature Communications","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Institute of Genetics; Canadian Institutes of Health Research; National Institutes of Health; National Center for Research Resources; American Heart Association; Circulation Foundation; Lawrence J. and Florence A. DeGeorge Charitable Trust; National Heart, Lung, and Blood Institute; Gladstone Institutes; California Institute for Regenerative Medicine","keywords":"Transcription factor; Haploinsufficiency; Heart development; Chromatin; Biology; TBX1; Zebrafish; Genetics; Chromatin remodeling; Cell biology; Promoter; Gene; Transcription (linguistics); Phenotype; Gene expression; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002418818,0.0003207258,0.0002708252,0.000362108,0.0001386316,0.0004831013,0.0002957625,0.0004184553,0.001666447],"category_scores_gemma":[0.0003426761,0.000290914,0.0001393191,0.0001269463,0.0003562555,0.0003286049,0.000369852,0.0003246815,0.0004365354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004638671,"about_ca_system_score_gemma":0.0001326027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005680123,"about_ca_topic_score_gemma":0.001273385,"domain_scores_codex":[0.9997478,0.00005410471,0.00002112593,0.00007453246,0.00006104747,0.0000414819],"domain_scores_gemma":[0.9997557,0.00006120294,0.00007195806,0.00003891736,0.00001827258,0.00005403774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000445729,0.000004035289,0.0003893374,0.00000937757,0.000003107261,0.00001531977,0.000008805497,0.00002719666,0.9985825,0.00006497149,0.00001300702,0.0008378036],"study_design_scores_gemma":[0.00003476342,0.0001740395,0.06462405,0.0000101197,0.00003352283,0.0003489017,0.00004049889,0.001252665,0.9314928,0.0001904198,0.001784055,0.00001423414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931222,0.002901146,0.001995435,0.0001379855,0.00002298171,0.00001055574,0.0002176468,0.00007147393,0.001520557],"genre_scores_gemma":[0.9971293,0.0007120814,0.0006094782,0.00004787139,0.000008513161,0.000009533695,0.0001623602,0.00003102794,0.001289816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001666447,"threshold_uncertainty_score":0.005574882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08250980139244724,"score_gpt":0.3205444382893215,"score_spread":0.2380346368968743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}