{"id":"W2114446999","doi":"10.1200/jco.2012.48.1390","title":"Pooled Analysis of the Prognostic and Predictive Effects of <i>KRAS</i> Mutation Status and <i>KRAS</i> Mutation Subtype in Early-Stage Resected Non–Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":292,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Canadian Cancer Society Research Institute; Institut National Du Cancer; National Cancer Institute; Ligue Contre le Cancer; Sanofi","keywords":"KRAS; Medicine; Hazard ratio; Internal medicine; Mutation; Oncology; Proportional hazards model; Cancer; Lung cancer; Stage (stratigraphy); Gastroenterology; Genetics; Colorectal cancer; Gene; Biology; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001774351,0.0001214141,0.001778747,0.0003540882,0.0000154819,0.000005124569,0.0000632942,0.0002050935,0.00002641761],"category_scores_gemma":[0.003322655,0.00007405725,0.0002421637,0.0006462637,0.0001623075,0.0001099777,0.00002101182,0.0003249763,8.244468e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001398657,"about_ca_system_score_gemma":0.001042836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001569798,"about_ca_topic_score_gemma":0.001048824,"domain_scores_codex":[0.9963161,0.0008076302,0.002296756,0.0001656015,0.0002583298,0.0001556253],"domain_scores_gemma":[0.991764,0.004480101,0.002936597,0.0001192787,0.0005821006,0.0001179195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002482948,0.0009617358,0.9700509,0.000307612,0.002443863,0.00004163783,0.002505168,0.0008150961,0.006454626,0.000003867171,0.00003181598,0.01390072],"study_design_scores_gemma":[0.01676302,0.004291983,0.965371,0.0004018675,0.006444897,0.00000455282,0.000272763,0.0031129,0.00320191,0.00007050286,0.00001279117,0.00005187908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958665,0.001676096,0.0001307923,0.0006228924,0.0001846063,0.001404189,0.00003591963,0.000001795741,0.00007725392],"genre_scores_gemma":[0.9974291,0.001848115,0.0004142169,0.0001531576,0.00005249162,0.0000435758,0.000007013716,0.0000109669,0.00004141293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01428007,"threshold_uncertainty_score":0.3977768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03267135251306558,"score_gpt":0.4231156361453118,"score_spread":0.3904442836322463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}