{"id":"W2114527746","doi":"10.1093/nar/gkp283","title":"Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases λ and μ for nonhomologous end joining in human whole-cell extracts","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; U.S. Department of Health and Human Services","keywords":"Biology; Polymerase; Non-homologous end joining; DNA polymerase; Recombinant DNA; DNA; Molecular biology; DNA polymerase mu; DNA repair; DNA ligase; Sticky and blunt ends; Genetics; Gene; Circular bacterial chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001422514,0.0001945503,0.0002286176,0.0002101988,0.0001720893,0.0000634102,0.0002639579,0.0002405871,0.000022903],"category_scores_gemma":[0.0002043616,0.0002070577,0.00007102169,0.0001382121,0.00009515631,0.00001173972,0.00009253349,0.0001892961,0.000002117317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009746198,"about_ca_system_score_gemma":0.0001025632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005577442,"about_ca_topic_score_gemma":0.00005630419,"domain_scores_codex":[0.9977498,0.000141662,0.0003624351,0.0006427208,0.0003310634,0.0007723329],"domain_scores_gemma":[0.9992532,0.0001113225,0.00006999024,0.0003468667,0.00008714335,0.0001314995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002539178,0.0002979995,0.0004605037,0.00005736435,0.000008391937,0.00001156852,0.00008693021,0.0000207852,0.9903883,0.0001062872,0.001816695,0.00649125],"study_design_scores_gemma":[0.002998004,0.002365388,0.000298173,0.00007110766,0.000005454368,0.000002819892,0.0002443196,0.001033922,0.9866935,0.0005603872,0.005493361,0.0002335623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952359,0.0008902381,0.001379637,0.0005593178,0.00003591904,0.001164219,0.00007411187,0.0000154476,0.0006451793],"genre_scores_gemma":[0.9952617,0.00003854849,0.002994862,0.0003374545,0.00008605916,0.0002294784,0.0002534429,0.00004194711,0.0007565511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006257688,"threshold_uncertainty_score":0.844357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05695678066336515,"score_gpt":0.3537838837210779,"score_spread":0.2968271030577128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}