{"id":"W2114553251","doi":"10.1158/1078-0432.ccr-07-0547","title":"Relationship of<i>EGFR</i>Mutations, Expression, Amplification, and Polymorphisms to Epidermal Growth Factor Receptor Inhibitors in the NCI60 Cell Lines","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Erlotinib; Epidermal growth factor receptor; Biology; EGFR inhibitors; Cancer research; Tyrosine kinase; Molecular biology; Gene; Lung cancer; Cancer; Genetics; Receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002746799,0.0001197061,0.0002644136,0.0003100079,0.0002082802,0.00002801966,0.0001659722,0.0001402074,0.0001095576],"category_scores_gemma":[0.002381918,0.00008017542,0.00007730904,0.0009653197,0.0003021381,0.0001052269,0.00005884843,0.000552306,0.00003269309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602243,"about_ca_system_score_gemma":0.0004731147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006729902,"about_ca_topic_score_gemma":0.0001890902,"domain_scores_codex":[0.9974399,0.0003640208,0.0008331235,0.0003859037,0.0006227397,0.0003542828],"domain_scores_gemma":[0.995142,0.003507956,0.0001204015,0.0003556869,0.0006003357,0.0002736102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003912537,0.0004685137,0.9734902,0.00008556627,0.00001960254,0.00000892457,0.002844832,0.000005022127,0.003415566,0.0006779167,0.0113898,0.007202845],"study_design_scores_gemma":[0.001512946,0.0003436658,0.9772239,0.000164191,0.0000367309,0.000002759937,0.00133362,0.000005091902,0.01020199,0.0005897403,0.008485396,0.0001000197],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802194,0.001646938,0.0003581689,0.01530436,0.00020858,0.001178733,0.00005732502,0.00001896182,0.001007591],"genre_scores_gemma":[0.9962845,0.0002640606,0.001338283,0.0006278655,0.0004524207,0.0002198142,0.00004769882,0.00002083894,0.000744554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01606513,"threshold_uncertainty_score":0.3269459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1712660412785758,"score_gpt":0.5120324427055788,"score_spread":0.340766401427003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}