{"id":"W2114562795","doi":"10.1111/j.1365-2958.2004.04448.x","title":"The contribution of MvfR to <i>Pseudomonas aeruginosa</i> pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing‐regulated genes are modulated without affecting <i>lasRI</i>, <i>rhlRI</i> or the production of <i>N</i>‐acyl‐ <scp>l</scp>‐homoserine lactones","year":2005,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":425,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"","keywords":"Quorum sensing; Virulence; Pseudomonas aeruginosa; Biology; Homoserine; Microbiology; Gene; Mutant; Transcription (linguistics); Transcriptional regulation; Regulator; Transcription factor; Cell biology; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007248654,0.0004712128,0.0005899561,0.00009012828,0.0004895236,0.00005496831,0.0002202968,0.0004410177,0.000001218581],"category_scores_gemma":[0.0008879589,0.000309517,0.0001927368,0.0003959169,0.0005574544,0.00001863705,0.0003005283,0.0001854895,0.00000257295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003820645,"about_ca_system_score_gemma":0.00009219292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000615586,"about_ca_topic_score_gemma":0.0005015125,"domain_scores_codex":[0.9970313,0.0005653094,0.0007801469,0.0007965837,0.0001395858,0.0006870478],"domain_scores_gemma":[0.997588,0.0001894482,0.0007169708,0.0007942122,0.0006021982,0.0001091234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003170618,0.00005223196,0.001586605,0.00003648655,0.0001729324,0.000007086206,0.0001400773,0.0006833347,0.9895546,0.0000162884,0.0003540178,0.007079226],"study_design_scores_gemma":[0.0008285886,0.0002561072,0.003318981,0.0001052891,0.0001191736,0.0006614567,0.0003173751,0.0003198624,0.9714499,0.000006707088,0.02238175,0.0002348686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937314,0.001883974,0.001042997,0.001724254,0.0005740552,0.0009174157,0.00006342564,0.00004665182,0.00001580886],"genre_scores_gemma":[0.9969437,0.0002078353,0.001548389,0.0005064187,0.0003167475,0.000005033667,0.0002357955,0.00006966227,0.0001664731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02202773,"threshold_uncertainty_score":0.9999357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006073895966956263,"score_gpt":0.206747144132863,"score_spread":0.2006732481659068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}