{"id":"W2114577256","doi":"10.1093/carcin/bgq125","title":"Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Queen's University; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; University of Alberta; McKnight Foundation","keywords":"Multidrug resistance-associated protein 2; Glutathione; Arsenite; Biochemistry; Chemistry; Efflux; Selenium; Arsenic; ATP-binding cassette transporter; Biology; Enzyme; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002576306,0.0002548049,0.0002840926,0.000300074,0.0001731093,0.0004857502,0.0002334208,0.000776128,0.0009711121],"category_scores_gemma":[0.000312755,0.000185216,0.0002586564,0.0002913801,0.0003742668,0.0007123249,0.0003197189,0.0003724299,0.0003623359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003748649,"about_ca_system_score_gemma":0.0002169961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005377334,"about_ca_topic_score_gemma":0.0005561607,"domain_scores_codex":[0.9998454,0.00004712254,0.00001356829,0.00003289109,0.00003331135,0.00002777187],"domain_scores_gemma":[0.999889,0.0000221887,0.00002578784,0.00001413337,0.0000284584,0.00002038625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000520346,0.00006776587,0.004268254,0.0001558367,0.00003191322,0.0006244343,0.00007409156,0.0002005435,0.986761,0.001074113,0.0003406697,0.00588101],"study_design_scores_gemma":[0.0002861544,0.002120844,0.1078037,0.00004713373,0.0001854331,0.01206214,0.0005472771,0.01246583,0.8419126,0.003180725,0.01928988,0.00009831405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838044,0.009276136,0.003723197,0.001245225,0.00004476887,0.00003486324,0.0002719859,0.00009555749,0.001503716],"genre_scores_gemma":[0.9942002,0.002467218,0.001632427,0.0001171474,0.0000346515,0.0000263266,0.0002656462,0.00001256616,0.001243826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009711121,"threshold_uncertainty_score":0.003248692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490674162615305,"score_gpt":0.2557069620907802,"score_spread":0.2408002204646272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}