{"id":"W2114577256","doi":"10.1093/carcin/bgq125","title":"Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Queen's University; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; University of Alberta; McKnight Foundation","keywords":"Multidrug resistance-associated protein 2; Glutathione; Arsenite; Biochemistry; Chemistry; Efflux; Selenium; Arsenic; ATP-binding cassette transporter; Biology; Enzyme; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005831099,0.0002445103,0.0004132878,0.00008110028,0.000332406,0.00001127638,0.0002526135,0.0001727038,0.00001522023],"category_scores_gemma":[0.00002758749,0.0001558653,0.000168045,0.0002035117,0.0003717141,0.00006021868,0.00001891259,0.0002408616,5.859364e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002549368,"about_ca_system_score_gemma":0.0001213827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007661375,"about_ca_topic_score_gemma":0.001357638,"domain_scores_codex":[0.9983072,0.00003765695,0.0005907145,0.0004479247,0.0003286474,0.0002878488],"domain_scores_gemma":[0.9984183,0.0001454801,0.00029856,0.000729675,0.000283324,0.0001247039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001950783,0.0001288587,0.01889269,0.0003225512,0.0001086238,6.298403e-7,0.0006696887,0.000001392409,0.975629,0.002941662,0.00008952642,0.001020318],"study_design_scores_gemma":[0.001406661,0.00008055103,0.3307928,0.0000520116,0.0005936151,0.00001816122,0.0006297015,0.0000366977,0.6645267,0.0002843101,0.001410766,0.000167953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911687,0.002330787,0.001973049,0.001687318,0.00008526782,0.002329703,0.0002893083,0.00003239224,0.0001034562],"genre_scores_gemma":[0.9963986,0.0002529673,0.0008631925,0.00004281967,0.0000731131,0.0004347914,0.00007151856,0.00004522185,0.001817799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3119001,"threshold_uncertainty_score":0.6356003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490674162615305,"score_gpt":0.2557069620907802,"score_spread":0.2408002204646272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}