{"id":"W2114583616","doi":"10.1586/17474086.2014.951322","title":"Alprolix (recombinant Factor IX Fc fusion protein): extended half-life product for the prophylaxis and treatment of hemophilia B","year":2014,"lang":"en","type":"article","venue":"Expert Review of Hematology","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Factor IX; Recombinant DNA; Genetic enhancement; Fusion protein; Coagulation; Disease; Internal medicine; Immunology; Pharmacology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006977232,0.0004555195,0.0006573448,0.00122013,0.0001894535,0.0006294613,0.0005640693,0.00117457,0.003552188],"category_scores_gemma":[0.0005469507,0.00009481313,0.0003288068,0.0008785831,0.0003180475,0.0004280326,0.0002648836,0.001078121,0.003218041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003984894,"about_ca_system_score_gemma":0.0004998146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005453307,"about_ca_topic_score_gemma":0.0008191282,"domain_scores_codex":[0.9997203,0.00005675579,0.00002085507,0.00004275389,0.0001384742,0.00002081585],"domain_scores_gemma":[0.9997186,0.00009390921,0.00006996613,0.000007721611,0.00007514435,0.00003452984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001592452,0.0001382064,0.000304799,0.002940565,0.00008001193,0.0003799581,0.00004895002,0.0001579621,0.007458178,0.003294398,0.05202225,0.9330155],"study_design_scores_gemma":[0.00009270953,0.000256039,0.0008702006,0.0005952473,0.00006266093,0.003225779,0.00002627349,0.00006206388,0.002450009,0.0006921703,0.9916552,0.00001169475],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00114995,0.9888536,0.0008701059,0.001473852,0.0006677412,0.00002590855,0.00004431791,0.00003011171,0.006884447],"genre_scores_gemma":[0.01097102,0.9741578,0.001704901,0.001690119,0.001279927,0.00003809221,0.0001776613,0.00001200471,0.009968527],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003552188,"threshold_uncertainty_score":0.01188326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03703268248659912,"score_gpt":0.3518018188470474,"score_spread":0.3147691363604482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}