{"id":"W2114590352","doi":"10.3899/jrheum.140238","title":"A Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of 2 Dosing Regimens of Fostamatinib in Patients with Rheumatoid Arthritis with an Inadequate Response to a Tumor Necrosis Factor-α Antagonist","year":2014,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; AstraZeneca (Canada)","funders":"Astellas Pharma; Ablynx; Sanofi; Genentech; AstraZeneca; Servier; Amgen; Pfizer; Bristol-Myers Squibb","keywords":"Medicine; Placebo; Rheumatoid arthritis; Internal medicine; Rheumatology; Clinical endpoint; Adverse effect; Syk; Methotrexate; Gastroenterology; Dosing; Randomized controlled trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003237954,0.002213018,0.003823337,0.0005969799,0.0007646486,0.001133764,0.001174345,0.001890058,0.00533679],"category_scores_gemma":[0.002449988,0.001100062,0.001776139,0.0005600888,0.001651578,0.00158783,0.0003996576,0.003161466,0.0009819804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009750317,"about_ca_system_score_gemma":0.001849763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006248084,"about_ca_topic_score_gemma":0.001719599,"domain_scores_codex":[0.9987753,0.0006084281,0.00008442071,0.0002490187,0.0001147176,0.0001680192],"domain_scores_gemma":[0.9988452,0.0002498079,0.0002854615,0.0001305269,0.00009697142,0.0003920861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9551544,0.0260903,0.0006007877,0.0003666446,0.0006641899,0.00003427626,0.00007619947,0.0003177032,0.005250934,0.00008172672,0.000576633,0.01078626],"study_design_scores_gemma":[0.9318944,0.06663999,0.0007255188,0.000005981036,0.00008975128,0.00001737814,0.000009445345,0.0001796227,0.0002052997,0.00004634899,0.0001775522,0.000008737134],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870243,0.001729115,0.001242803,0.0004765953,0.0004953907,0.007002397,0.000902754,0.000136637,0.0009899611],"genre_scores_gemma":[0.980345,0.001136426,0.003405642,0.001147162,0.000445999,0.01079183,0.0008773757,0.0000331943,0.001817349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00533679,"threshold_uncertainty_score":0.01785332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620368944139127,"score_gpt":0.2913915961262542,"score_spread":0.2751879066848629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}