{"id":"W2114591167","doi":"10.1128/jvi.01753-08","title":"Orthopoxviruses Require a Functional Ubiquitin-Proteasome System for Productive Replication","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Howard Hughes Medical Institute","keywords":"MG132; Biology; Ubiquitin; Proteasome; Lactacystin; Proteasome inhibitor; Viral replication; Cell biology; Aggresome; Bortezomib; Protein degradation; Virology; Virus; Gene; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002451684,0.0004006966,0.0003053568,0.0001718497,0.000220247,0.0005348119,0.0001962083,0.0003964348,0.0007327634],"category_scores_gemma":[0.0002225542,0.0001853491,0.0002073806,0.0001147133,0.0002357606,0.0004007713,0.0003100433,0.0006075259,0.0004451372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003310592,"about_ca_system_score_gemma":0.000228305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092831,"about_ca_topic_score_gemma":0.0003555857,"domain_scores_codex":[0.9997796,0.00003964692,0.00002686091,0.00003505381,0.00007134479,0.00004750752],"domain_scores_gemma":[0.9998807,0.00002693242,0.00003136401,0.00001833954,0.00001609342,0.00002658278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002376238,0.00001084905,0.0001218643,0.00002474374,0.000001845933,0.00003932296,0.000007663799,0.00002073554,0.9987929,0.0001325022,0.00001879072,0.0008048869],"study_design_scores_gemma":[0.00002177096,0.0002962612,0.007741857,0.00001234072,0.00001311636,0.0006906272,0.00003950315,0.0007981918,0.983776,0.0002078741,0.006396258,0.000006104684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816077,0.003497495,0.01163354,0.000133498,0.00008364804,0.0001105172,0.0004695706,0.0001458985,0.002318089],"genre_scores_gemma":[0.9824517,0.001394146,0.01115155,0.00007382344,0.00003711128,0.00009517689,0.00133855,0.00003142357,0.003426469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007327634,"threshold_uncertainty_score":0.002451301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05007402258689201,"score_gpt":0.2919407179837307,"score_spread":0.2418666953968387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}