{"id":"W2114610097","doi":"10.1038/ncb2092","title":"Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells","year":2010,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":337,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Biotechnology and Biological Sciences Research Council; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Wellcome Trust","keywords":"Cell biology; Mitosis; Protein phosphatase 2; Mitotic exit; Biology; Importin; Polo-like kinase; Cyclin-dependent kinase 1; Cell cycle; Phosphatase; Spindle apparatus; Nuclear transport; Cell nucleus; Phosphorylation; Cell division; Cell; Biochemistry; Nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001593972,0.0004713336,0.0004689745,0.0003782099,0.000328228,0.0005449189,0.0002935679,0.0003829385,0.001600392],"category_scores_gemma":[0.0001354973,0.000306899,0.0003267394,0.0002096173,0.0002828915,0.0001897817,0.0001798626,0.0004937348,0.0006557497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003676211,"about_ca_system_score_gemma":0.0002746154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002324823,"about_ca_topic_score_gemma":0.003239273,"domain_scores_codex":[0.9998566,0.000008847612,0.00001333741,0.00005744962,0.00003942412,0.00002430024],"domain_scores_gemma":[0.9998883,0.00002401054,0.00003054734,0.00001375245,0.00001569117,0.00002773162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006079726,0.00001253191,0.0002402389,0.00001420162,0.00000752105,0.00009923787,0.00000691583,0.00004597668,0.9983525,0.00006746317,0.00009113016,0.001001548],"study_design_scores_gemma":[0.00001751529,0.00006307248,0.006221009,0.000003010908,0.00004770645,0.0005987466,0.00001745325,0.0009485002,0.9905336,0.00004338518,0.001501915,0.000004129096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805257,0.001893098,0.01232477,0.000238621,0.00004192557,0.00006009973,0.00176242,0.0003848685,0.002768467],"genre_scores_gemma":[0.9854686,0.0009048182,0.007684034,0.0001606223,0.00001335988,0.00003563627,0.001305016,0.0001200408,0.004307797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002324823,"threshold_uncertainty_score":0.005353808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002394731970891805,"score_gpt":0.2302725366969224,"score_spread":0.2278778047260306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}