{"id":"W2114622090","doi":"10.1158/1078-0432.ccr-04-1284","title":"Antitumor Efficacy of <i>bcl-2</i> and <i>c-myc</i> Antisense Oligonucleotides in Combination with Cisplatin in Human Melanoma Xenografts: Relevance of the Administration Sequence","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada)","funders":"Associazione Italiana per la Ricerca sul Cancro; Consiglio Nazionale delle Ricerche; Ministero della Salute","keywords":"Melanoma; Oligonucleotide; Cancer research; Cisplatin; Messenger RNA; Apoptosis; Molecular biology; Biology; N-Myc; Medicine; Chemotherapy; Cell culture; Gene; Internal medicine; Biochemistry; Neuroblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009258968,0.00008767646,0.0001972594,0.00003877149,0.00004419568,0.000009714983,0.0002207032,0.0001216317,0.000006852218],"category_scores_gemma":[0.0003077493,0.00006735866,0.00003974435,0.0002603045,0.0006947597,0.00000969967,0.0001042458,0.0002911767,3.810615e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002208068,"about_ca_system_score_gemma":0.0001839266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009828541,"about_ca_topic_score_gemma":0.0007138107,"domain_scores_codex":[0.9985873,0.0001805909,0.0004774721,0.000302966,0.0002546755,0.0001969815],"domain_scores_gemma":[0.9992088,0.0001431143,0.0001463292,0.0003136362,0.0001390625,0.00004904748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007120925,0.0003626944,0.2021838,0.00009720182,0.00001159915,0.000005814179,0.00004919249,0.00003539187,0.7909656,0.00008413123,0.0002640489,0.005228445],"study_design_scores_gemma":[0.002230195,0.0006353573,0.1913318,0.0002707709,0.000005832329,0.000006053756,0.00005599482,0.00006613896,0.8037853,0.00005243815,0.001460318,0.000099764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981712,0.0005324743,0.000003417103,0.0005819399,0.00002351853,0.0002303877,0.00001496563,0.000002384401,0.0004396869],"genre_scores_gemma":[0.9988524,0.0006963492,0.0001722488,0.00004714237,0.00008564347,0.00001484886,0.00001098573,0.00001137739,0.0001089963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01281971,"threshold_uncertainty_score":0.2746807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06126924746794386,"score_gpt":0.4245529808550566,"score_spread":0.3632837333871127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}