{"id":"W2114622090","doi":"10.1158/1078-0432.ccr-04-1284","title":"Antitumor Efficacy of <i>bcl-2</i> and <i>c-myc</i> Antisense Oligonucleotides in Combination with Cisplatin in Human Melanoma Xenografts: Relevance of the Administration Sequence","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada)","funders":"Associazione Italiana per la Ricerca sul Cancro; Consiglio Nazionale delle Ricerche; Ministero della Salute","keywords":"Melanoma; Oligonucleotide; Cancer research; Cisplatin; Messenger RNA; Apoptosis; Molecular biology; Biology; N-Myc; Medicine; Chemotherapy; Cell culture; Gene; Internal medicine; Biochemistry; Neuroblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002816082,0.0004091423,0.0005180282,0.0002450912,0.0001297065,0.0002809972,0.0002364934,0.0003478182,0.0006805018],"category_scores_gemma":[0.0001964408,0.0001686077,0.0002113341,0.0001403219,0.0002636296,0.0002065952,0.0001222022,0.0005458872,0.0001561225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615325,"about_ca_system_score_gemma":0.0002758979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005530833,"about_ca_topic_score_gemma":0.0009888012,"domain_scores_codex":[0.9997945,0.00006415841,0.00002330775,0.00003760968,0.00004867249,0.00003167152],"domain_scores_gemma":[0.9998443,0.0000398115,0.00003306204,0.00001490706,0.00001374612,0.00005417784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001573485,0.0004742747,0.0004783375,0.00007167009,0.00002318441,0.00002888,0.00002805432,0.0004452655,0.9930558,0.00005982056,0.0000752548,0.003685965],"study_design_scores_gemma":[0.0003940543,0.01513768,0.003215498,0.00001169304,0.00007683492,0.0001703882,0.00002207768,0.001571124,0.9780141,0.00002097377,0.001356331,0.000009156298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975929,0.001050453,0.000366655,0.00004372705,0.00003175776,0.00005011888,0.0000697659,0.00003369495,0.0007608943],"genre_scores_gemma":[0.9972957,0.0006824588,0.001028091,0.00003025442,0.00002121013,0.00005161659,0.0001485909,0.00001189804,0.0007303255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006805018,"threshold_uncertainty_score":0.00227654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06126924746794386,"score_gpt":0.4245529808550566,"score_spread":0.3632837333871127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}