{"id":"W2114639903","doi":"10.1055/s-2004-823104","title":"The Pathogenesis of Nonalcoholic Steatohepatitis and Other Fatty Liver Diseases: A Four-Step Model including the Role of Lipid Release and Hepatic Venular Obstruction in the Progression to Cirrhosis","year":2004,"lang":"en","type":"review","venue":"Seminars in Liver Disease","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"Steatosis; Cirrhosis; Steatohepatitis; Fatty liver; Nonalcoholic fatty liver disease; Medicine; Fibrosis; Necrosis; Internal medicine; Pathology; Gastroenterology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001031384,0.001420194,0.0005956554,0.001037041,0.0004421447,0.001109655,0.0009428231,0.001473549,0.002068495],"category_scores_gemma":[0.000332065,0.0002838257,0.0008046309,0.0004033548,0.002024575,0.001742664,0.001063306,0.00112304,0.0007602792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007353275,"about_ca_system_score_gemma":0.0009311372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006513489,"about_ca_topic_score_gemma":0.0007250051,"domain_scores_codex":[0.9996938,0.0001116973,0.00002922277,0.00004832718,0.000060915,0.00005611902],"domain_scores_gemma":[0.9997573,0.00005291048,0.00006361586,0.00002485589,0.00003583061,0.00006538304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002742755,0.001571768,0.03514802,0.006562048,0.0005203321,0.01414862,0.002177008,0.01888799,0.2878001,0.3358436,0.02305016,0.2715476],"study_design_scores_gemma":[0.0007861897,0.01137057,0.05173602,0.001094945,0.0007282023,0.03813328,0.002268836,0.1174552,0.102537,0.4576492,0.2159123,0.0003281429],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.3508016,0.2165073,0.3472631,0.0414942,0.005817572,0.002127262,0.0007827305,0.002394923,0.03281136],"genre_scores_gemma":[0.80235,0.08509247,0.08057173,0.003583591,0.001743963,0.0008948935,0.0004097457,0.00006226239,0.02529132],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002068495,"threshold_uncertainty_score":0.006919801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03063878090072775,"score_gpt":0.3078000392970124,"score_spread":0.2771612583962847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}