{"id":"W2114645683","doi":"10.1158/1078-0432.ccr-12-3114","title":"Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Astex Pharmaceuticals; AstraZeneca","keywords":"Autophagy; Protein kinase B; Prostate; Cancer research; PI3K/AKT/mTOR pathway; Medicine; Chemistry; Biology; Cell biology; Signal transduction; Cancer; Internal medicine; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001242517,0.0003949793,0.0005491991,0.0003336927,0.0001664687,0.0003179932,0.0002099594,0.0002482635,0.0007647692],"category_scores_gemma":[0.00007695588,0.0001508862,0.0003398591,0.0002915657,0.0002358355,0.000203099,0.0001519494,0.0005317253,0.0002549065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003076328,"about_ca_system_score_gemma":0.0002436026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005908089,"about_ca_topic_score_gemma":0.001068924,"domain_scores_codex":[0.9998689,0.00001724865,0.00002025561,0.00002724429,0.00004163512,0.00002470865],"domain_scores_gemma":[0.9999367,0.000009021031,0.00002274476,0.00001153807,0.000006935846,0.00001308548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003206412,0.00009544315,0.0003433944,0.0000512489,0.00001831636,0.00005515603,0.00001640566,0.0002121165,0.9964503,0.00007269072,0.00006275764,0.002301661],"study_design_scores_gemma":[0.00006637055,0.001222309,0.003005744,0.000005244805,0.00004260848,0.0002507899,0.00001362319,0.0007795533,0.9932133,0.00002291431,0.001371959,0.000005483184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948821,0.002465908,0.001122868,0.00007808843,0.0000429076,0.00005186208,0.0003083113,0.0001359514,0.0009120521],"genre_scores_gemma":[0.9965265,0.001396765,0.001011541,0.00003169998,0.0000109524,0.00002951114,0.0003628702,0.00001273575,0.0006173233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007647692,"threshold_uncertainty_score":0.002558351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2763336418197235,"score_gpt":0.5225578416554204,"score_spread":0.2462241998356969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}