{"id":"W2114648756","doi":"10.2337/db09-1800","title":"Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Apocynin; NADPH oxidase; Internal medicine; Endocrinology; Diabetic cardiomyopathy; Endoplasmic reticulum; Fibrosis; RAC1; Oxidative stress; Type 2 diabetes; Unfolded protein response; Diabetes mellitus; Medicine; Reactive oxygen species; Chemistry; Signal transduction; Cardiomyopathy; Heart failure; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003518159,0.001080927,0.0006284009,0.0006924097,0.0002994707,0.0003623366,0.0005797841,0.0006231044,0.001751304],"category_scores_gemma":[0.0001519884,0.0003588324,0.0004409985,0.0002952486,0.0003545428,0.0003576052,0.0002367589,0.001338438,0.0004222913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003119924,"about_ca_system_score_gemma":0.0003310336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000454272,"about_ca_topic_score_gemma":0.0006994968,"domain_scores_codex":[0.9997076,0.00004988106,0.00003708663,0.00006890778,0.00006321959,0.0000733586],"domain_scores_gemma":[0.9997174,0.0000207961,0.0001173214,0.00002878911,0.00002431169,0.00009142635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009425853,0.0003601335,0.0003098431,0.0001128575,0.0000208243,0.00007531335,0.00002039813,0.00007317345,0.9951467,0.0001160692,0.0001067363,0.002715198],"study_design_scores_gemma":[0.0005020908,0.00486292,0.009184296,0.00007481006,0.0001423873,0.0006936727,0.00005975617,0.001883434,0.9774061,0.0001404255,0.005031809,0.00001837407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881927,0.004320415,0.004598306,0.0004488228,0.0001178984,0.00008882209,0.0006166904,0.0003168168,0.001299465],"genre_scores_gemma":[0.9745954,0.006839376,0.00904686,0.0002520914,0.00009462095,0.0003637346,0.001700357,0.0001152626,0.006992382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001751304,"threshold_uncertainty_score":0.005858719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065254319423427,"score_gpt":0.2315121507367721,"score_spread":0.2208596075425378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}