{"id":"W2114648756","doi":"10.2337/db09-1800","title":"Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Apocynin; NADPH oxidase; Internal medicine; Endocrinology; Diabetic cardiomyopathy; Endoplasmic reticulum; Fibrosis; RAC1; Oxidative stress; Type 2 diabetes; Unfolded protein response; Diabetes mellitus; Medicine; Reactive oxygen species; Chemistry; Signal transduction; Cardiomyopathy; Heart failure; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003835516,0.0002020627,0.0006031882,0.0002595115,0.00005067876,0.00001668285,0.0000815313,0.0001931463,0.000006484845],"category_scores_gemma":[0.0005443816,0.0001763352,0.0001305332,0.0002824157,0.0001842199,0.0001420032,0.00007832155,0.0003390462,6.002526e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000169633,"about_ca_system_score_gemma":0.0001462429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003463412,"about_ca_topic_score_gemma":0.000003976475,"domain_scores_codex":[0.998428,0.00003351699,0.0005487241,0.0003422284,0.0003105925,0.0003369556],"domain_scores_gemma":[0.9989325,0.0001391791,0.0001946467,0.0003058291,0.0003199661,0.0001078936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003630863,0.0001241158,0.05829909,0.0002305885,0.00002936039,1.265655e-7,0.0003996815,0.006305804,0.9335888,0.00005323538,0.00001724261,0.0009156599],"study_design_scores_gemma":[0.0007039979,0.00009295854,0.002135102,0.0004243392,0.00006467253,4.555054e-7,0.0001324288,0.1529242,0.8431987,0.0001727486,0.000002877902,0.0001474712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984782,0.0006277584,0.00001278612,0.0001099614,0.000126021,0.0002998101,0.00005250664,0.00002836256,0.0002646373],"genre_scores_gemma":[0.9973482,0.0001471184,0.002282749,0.0000418906,0.00007694853,0.000009538038,0.00003055058,0.00003157292,0.00003139461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1466184,"threshold_uncertainty_score":0.7190742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065254319423427,"score_gpt":0.2315121507367721,"score_spread":0.2208596075425378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}