{"id":"W2114719792","doi":"10.1101/gad.215400.113","title":"Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation","year":2013,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Mef2; Gene isoform; Transcription factor; Cell biology; Alternative splicing; Transactivation; RNA splicing; Phosphorylation; Chromatin immunoprecipitation; Regulation of gene expression; Genetics; Gene expression; Enhancer; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002873701,0.0003884771,0.0003181542,0.0002370996,0.0002304933,0.0004268944,0.0002644178,0.0003195071,0.00207873],"category_scores_gemma":[0.0002484873,0.0002201057,0.0003181518,0.0002279279,0.0003410989,0.0002288451,0.0004394624,0.0004611124,0.001859733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961897,"about_ca_system_score_gemma":0.0003360965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002190037,"about_ca_topic_score_gemma":0.0004775852,"domain_scores_codex":[0.9995824,0.00005162926,0.00005284878,0.0001365631,0.0001281572,0.00004835914],"domain_scores_gemma":[0.9996836,0.00004396156,0.0001022008,0.00006745013,0.0000383603,0.00006441847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002043355,0.000007062428,0.0002029937,0.00002546018,0.000002804336,0.00007077352,0.000007465104,0.00002147508,0.9970195,0.0002560495,0.00005860593,0.002307301],"study_design_scores_gemma":[0.00001897586,0.0001885413,0.01102881,0.00002351664,0.00002242108,0.001417165,0.00003825779,0.001002186,0.9601696,0.0003869272,0.0256935,0.00001007403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8874983,0.01507058,0.08026688,0.0007815243,0.000454531,0.0001676362,0.002967602,0.001130686,0.01166237],"genre_scores_gemma":[0.973975,0.002871203,0.01481144,0.0001911028,0.00007359635,0.00007600812,0.002003555,0.0001562433,0.005841921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00207873,"threshold_uncertainty_score":0.006954074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0189255383718996,"score_gpt":0.2586242914514739,"score_spread":0.2396987530795743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}