{"id":"W2114733747","doi":"10.4049/jimmunol.1003034","title":"Akt-Mediated Proinflammatory Response of Mononuclear Phagocytes Infected with <i>Burkholderia cenocepacia</i> Occurs by a Novel GSK3β-Dependent, IκB Kinase-Independent Mechanism","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Ohio State University; National Institutes of Health; Great Lakes Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research; American Cancer Society","keywords":"Burkholderia cenocepacia; Proinflammatory cytokine; Protein kinase B; Biology; Microbiology; Immunology; Inflammation; PI3K/AKT/mTOR pathway; Macrophage; CCL2; Chemokine; Phosphorylation; Cancer research; Signal transduction; Burkholderia; Cell biology; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870253,0.0002427773,0.0001515821,0.0001195234,0.000157746,0.000321702,0.0001060202,0.0001760003,0.001086429],"category_scores_gemma":[0.00008233589,0.0001372215,0.000256824,0.00009022445,0.0002332028,0.000190277,0.0001636629,0.000474129,0.0002702083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002237566,"about_ca_system_score_gemma":0.0002842371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004169205,"about_ca_topic_score_gemma":0.0005399236,"domain_scores_codex":[0.9999096,0.00001731039,0.000008371475,0.00001377572,0.00001819198,0.00003269361],"domain_scores_gemma":[0.9999585,0.000004848502,0.00001541741,0.000005434737,0.00000490145,0.00001095014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004987247,0.00004651525,0.0006566869,0.00007210383,0.000007509322,0.00008223858,0.00001576279,0.00003473223,0.9973131,0.0001410924,0.00006015418,0.001071399],"study_design_scores_gemma":[0.0002093151,0.0009200061,0.04660974,0.00002881303,0.00004034957,0.001178563,0.00008669549,0.00116237,0.9456852,0.0002728035,0.003794572,0.00001144357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945018,0.002610066,0.001120351,0.0002096848,0.0000413462,0.00002854315,0.0002056009,0.00003308049,0.001249581],"genre_scores_gemma":[0.9967661,0.001262929,0.0008192353,0.00007419942,0.0000133897,0.00002499143,0.0002130085,0.000004047194,0.000822201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086429,"threshold_uncertainty_score":0.003634393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681151689100005,"score_gpt":0.2485329019152553,"score_spread":0.2317213850242552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}