{"id":"W2114782417","doi":"10.1042/bj3460509","title":"Mutations in the reduced-folate carrier affect protein localization and stability","year":2000,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Biology; Endoplasmic reticulum; Mutant; Chinese hamster ovary cell; Point mutation; Mutation; Gene; Mutant protein; Molecular biology; Wild type; Gene product; Allele; Genetics; Gene expression; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004447331,0.00006991403,0.0001094269,0.00004130484,0.00008171568,0.00004582223,0.00006635972,0.00004675864,0.0003679526],"category_scores_gemma":[0.0005870372,0.00004347285,0.00003443304,0.0002050686,0.0001536322,0.00007238545,0.00001040935,0.0003246215,0.000005349127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007068174,"about_ca_system_score_gemma":0.00008912661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000120912,"about_ca_topic_score_gemma":0.00000279748,"domain_scores_codex":[0.9990729,0.0001253246,0.0001879319,0.0001268791,0.000304869,0.0001820888],"domain_scores_gemma":[0.9995727,0.00009211689,0.00002716787,0.0001177573,0.00005840979,0.0001318806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005031482,0.0001674862,0.005453781,0.00007285302,0.00001677304,0.00005708319,0.000664601,0.000008832569,0.9702975,0.00002891001,0.0007946782,0.02193439],"study_design_scores_gemma":[0.005784113,0.001580991,0.1285762,0.0009706295,0.0001069517,0.003363375,0.001397119,0.003799391,0.8365368,0.007405545,0.01003927,0.0004396453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997068,0.0006540474,0.0002044999,0.001375693,0.00001122714,0.000357036,0.000005656559,0.000008391323,0.000315482],"genre_scores_gemma":[0.9989901,0.00005033747,0.0007024349,0.0000843887,0.0001014794,0.00001731148,0.000008660448,0.000006203854,0.0000390456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1337607,"threshold_uncertainty_score":0.4028823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754222170005833,"score_gpt":0.3162539515879569,"score_spread":0.2987117298878986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}