{"id":"W2114784474","doi":"10.1124/jpet.105.091256","title":"Modulation of Agonist Binding to Human Dopamine Receptor Subtypes by l-Prolyl-l-leucyl-glycinamide and a Peptidomimetic Analog","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McMaster University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Agonist; Receptor; Partial agonist; Chemistry; Endogenous agonist; Radioligand; Inverse agonist; Pharmacology; Biochemistry; Biology; Dopamine receptor D1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000234962,0.0001308672,0.0002120472,0.00008006081,0.0001046523,0.00001515791,0.00008949624,0.00009818944,0.0000984213],"category_scores_gemma":[0.000003215287,0.0001161403,0.00005550368,0.00005460124,0.00008064979,0.00001314323,0.00004864157,0.0000991205,0.000001001902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002803469,"about_ca_system_score_gemma":0.00002245617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002934721,"about_ca_topic_score_gemma":8.201008e-7,"domain_scores_codex":[0.9992145,0.00006746189,0.0003287886,0.0001460859,0.0000956727,0.0001475259],"domain_scores_gemma":[0.9995694,0.00001387054,0.0002223862,0.00005106231,0.00006065031,0.00008268186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004216673,0.0001336165,0.000360675,0.000007637217,0.0001440275,0.000001022461,0.0002439341,0.0000752851,0.9960375,0.00002386782,0.0005570832,0.001993716],"study_design_scores_gemma":[0.001292461,0.001440025,0.00009177001,0.000009918422,0.00005573596,0.00003933377,0.0002598978,0.0001684465,0.9886004,0.00001490682,0.007908531,0.0001185816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944305,0.004505313,0.0004708399,0.0002649401,0.0001731779,0.0001067277,0.000007924548,0.000002460888,0.00003809668],"genre_scores_gemma":[0.9967904,0.0004805437,0.001813775,0.0004842698,0.0002724219,0.000003416453,0.00001101496,0.00001508002,0.0001290907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007437075,"threshold_uncertainty_score":0.4736063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459135686158108,"score_gpt":0.3122178572088026,"score_spread":0.2976265003472215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}