{"id":"W2114806174","doi":"10.1074/jbc.m601019200","title":"24(S)-Hydroxycholesterol Participates in a Liver X Receptor-controlled Pathway in Astrocytes That Regulates Apolipoprotein E-mediated Cholesterol Efflux","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":264,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Rheinische Friedrich-Wilhelms-Universität Bonn; Internationale Stichting Alzheimer Onderzoek; Alzheimer Society","keywords":"Efflux; Liver X receptor; Apolipoprotein E; Cholesterol; Chemistry; Apolipoprotein B; ABCG1; ABCA1; Cell biology; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry; Nuclear receptor; Gene; Transporter; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344053,0.0002944239,0.0003464582,0.0002547165,0.0002476838,0.0003318245,0.0001087191,0.0002385319,0.001012052],"category_scores_gemma":[0.00009300401,0.0001206397,0.0003408134,0.0001628359,0.0001547952,0.0002001188,0.0001564437,0.0002250028,0.0006509012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002591484,"about_ca_system_score_gemma":0.0003222325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127205,"about_ca_topic_score_gemma":0.001468616,"domain_scores_codex":[0.999864,0.00003042168,0.0000161941,0.00002342569,0.00003158489,0.00003433051],"domain_scores_gemma":[0.99993,0.000005707274,0.00001605177,0.000007007706,0.00002323921,0.00001794575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002026744,0.00002127856,0.000490578,0.00006502956,0.000007508094,0.0002935889,0.00003892168,0.00003195357,0.9969113,0.0001389001,0.0000503967,0.001747918],"study_design_scores_gemma":[0.0000689799,0.0005050098,0.03841196,0.00002545984,0.00005783004,0.001297222,0.0003052451,0.0009956622,0.9498769,0.0004393124,0.007996884,0.00001959189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786752,0.01087501,0.004840022,0.0003622834,0.0001124128,0.0001026752,0.0005238982,0.0001266922,0.004381817],"genre_scores_gemma":[0.9878998,0.003903392,0.002557079,0.00009440062,0.00003757255,0.00007548773,0.0004933042,0.00001501984,0.004923973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127205,"threshold_uncertainty_score":0.003385663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02475696698287881,"score_gpt":0.2451092440628801,"score_spread":0.2203522770800013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}