{"id":"W2114806174","doi":"10.1074/jbc.m601019200","title":"24(S)-Hydroxycholesterol Participates in a Liver X Receptor-controlled Pathway in Astrocytes That Regulates Apolipoprotein E-mediated Cholesterol Efflux","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":264,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Rheinische Friedrich-Wilhelms-Universität Bonn; Internationale Stichting Alzheimer Onderzoek; Alzheimer Society","keywords":"Efflux; Liver X receptor; Apolipoprotein E; Cholesterol; Chemistry; Apolipoprotein B; ABCG1; ABCA1; Cell biology; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry; Nuclear receptor; Gene; Transporter; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009204567,0.0003996249,0.001432889,0.0001818733,0.0000328338,0.00004982686,0.0002637844,0.0005085127,0.0002447869],"category_scores_gemma":[0.0004796157,0.0002606594,0.0003760802,0.0003070745,0.0001899276,0.0001627175,0.00006963139,0.0009915421,0.00002151921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001600593,"about_ca_system_score_gemma":0.00009211656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007203412,"about_ca_topic_score_gemma":0.00002551444,"domain_scores_codex":[0.9970224,0.0001771964,0.001378168,0.0003834693,0.0004186376,0.0006201571],"domain_scores_gemma":[0.9984255,0.0002361252,0.0006654224,0.0002751978,0.000125174,0.0002725803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002635145,0.001097048,0.1854972,0.0001054208,0.00005863429,0.0001530369,0.0001209308,0.00005428736,0.8081378,0.00000284653,0.000198153,0.00193953],"study_design_scores_gemma":[0.02308315,0.000390794,0.3739707,0.0006656234,0.00004551445,0.0002948846,0.0001619626,0.0001448571,0.5982289,0.00007440371,0.002652771,0.0002864262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966109,0.001695274,0.000007966039,0.0007632401,0.0001569824,0.0004263779,0.00001178938,0.00003242902,0.0002950093],"genre_scores_gemma":[0.9977143,0.0001817585,0.0002360875,0.0003841321,0.0009980553,0.00005184504,0.00003488561,0.00002488678,0.0003740116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2099089,"threshold_uncertainty_score":0.9999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02475696698287881,"score_gpt":0.2451092440628801,"score_spread":0.2203522770800013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}