{"id":"W2114816051","doi":"10.1124/dmd.104.002568","title":"IMPACT OF ENDOTOXIN-INDUCED CHANGES IN P-GLYCOPROTEIN EXPRESSION ON DISPOSITION OF DOXORUBICIN IN MICE","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Kidney; Doxorubicin; Pharmacokinetics; P-glycoprotein; Lipopolysaccharide; Internal medicine; Endocrinology; Pharmacology; Excretion; Chemistry; Inflammation; Biology; Medicine; Multiple drug resistance; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002558987,0.000187456,0.0004946373,0.0004350578,0.00002450325,0.000005360791,0.00005266525,0.0001082441,0.00003834174],"category_scores_gemma":[0.00001091478,0.0001432924,0.0001037548,0.0002922198,0.0000367084,0.0001512986,0.00001127613,0.0001572438,0.000001857723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005116101,"about_ca_system_score_gemma":0.00003278308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000398655,"about_ca_topic_score_gemma":0.0004373308,"domain_scores_codex":[0.9988022,0.00006955883,0.0003868087,0.0002593684,0.0002635041,0.0002185439],"domain_scores_gemma":[0.9995153,0.0000290202,0.0001544988,0.0001706884,0.000044453,0.00008606334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001726058,0.0006431281,0.003123828,0.0001478387,0.0000119222,0.00001316893,0.001308447,0.00003967721,0.9842042,0.000572353,0.000007465135,0.008201912],"study_design_scores_gemma":[0.002335052,0.0001457996,0.3362125,0.0006671157,0.00003966214,0.000003680789,0.0001480878,0.000082425,0.6601612,0.00009657768,0.00001461856,0.00009333663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977244,0.0007996533,0.00006658249,0.0002928023,0.00005852594,0.0006158412,0.00004675598,0.00001495102,0.0003805543],"genre_scores_gemma":[0.9989547,0.0002815058,0.000394944,0.00005089134,0.00009558842,0.00004341883,0.0001052665,0.00001770857,0.00005597757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3330886,"threshold_uncertainty_score":0.5843294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008047246283749523,"score_gpt":0.2638430270130578,"score_spread":0.2557957807293083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}