{"id":"W2114843189","doi":"10.1517/14656566.2014.862233","title":"The mechanism, efficacy, and tolerability profile of agomelatine","year":2013,"lang":"en","type":"review","venue":"Expert Opinion on Pharmacotherapy","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Agomelatine; Tolerability; Medicine; Antidepressant; Melatonin; Major depressive disorder; Pharmacology; Internal medicine; Psychiatry; Adverse effect; Mood; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00030423,0.0004450387,0.0009813759,0.0001074184,0.0002415294,0.00006628838,0.0004159225,0.000189891,0.0005829808],"category_scores_gemma":[0.00008807893,0.000265494,0.0002629254,0.0002400288,0.0002172315,0.00008600282,0.00005895484,0.0004137101,0.0001384772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005403759,"about_ca_system_score_gemma":0.0001211577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006456487,"about_ca_topic_score_gemma":7.230317e-8,"domain_scores_codex":[0.9974414,0.0005174332,0.00068013,0.0006597738,0.0003496207,0.0003516975],"domain_scores_gemma":[0.9976083,0.001184912,0.0004549896,0.0005595136,0.00002914446,0.0001631076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002929732,0.0001184406,1.473358e-7,0.0004216299,0.00002335015,0.000001120787,0.0001970637,7.297708e-8,0.004919889,0.01155606,0.001933601,0.9807993],"study_design_scores_gemma":[0.0006329929,0.0001454583,7.926127e-7,0.001029752,0.000006095962,0.00002270066,0.00000657943,0.0000329027,0.03838651,0.00007555674,0.9593944,0.0002662954],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008231665,0.9951063,0.00002286885,0.0002004651,0.0015735,0.00218448,0.00005602415,0.00007285376,0.000701198],"genre_scores_gemma":[0.00008608056,0.9978364,0.0000577857,0.0004168175,0.0004090503,0.0004761379,0.000007960031,0.00007720711,0.0006325359],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9805331,"threshold_uncertainty_score":0.9999797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1051395835311818,"score_gpt":0.4029467488684872,"score_spread":0.2978071653373055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}