{"id":"W2114880854","doi":"10.3390/ijms130911844","title":"The Heterochromatic Barrier to DNA Double Strand Break Repair: How to Get the Entry Visa","year":2012,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Canadian Institutes of Health Research; Alberta Cancer Foundation; Wellcome Trust","keywords":"Chromatin; Homologous recombination; DNA repair; DNA damage; Cell biology; Heterochromatin; Biology; DNA; Ku80; Homology directed repair; Molecular biology; Nucleotide excision repair; Genetics; DNA-binding protein; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001730645,0.000286787,0.0004040278,0.0001543571,0.0002043308,0.0005094079,0.002574676,0.0001380156,0.00001852658],"category_scores_gemma":[0.0002186928,0.0001505597,0.0007575881,0.0001997597,0.0001740422,0.00002463433,0.000429512,0.0002143006,0.00002298097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006555211,"about_ca_system_score_gemma":0.0004193941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004104633,"about_ca_topic_score_gemma":0.00001374771,"domain_scores_codex":[0.9973585,0.0002301318,0.0005684287,0.0003272209,0.001167879,0.0003478166],"domain_scores_gemma":[0.998395,0.00007555869,0.0005448284,0.0004105018,0.0003330208,0.0002410496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002270195,0.0002109114,0.00002257623,0.0005001432,0.003295521,0.000251673,0.0004712758,0.0002430078,0.05776095,0.001862695,0.009928795,0.9252254],"study_design_scores_gemma":[0.0001826909,0.0003176547,0.00000391255,0.000748479,0.0001932755,0.0008726946,0.0001009319,0.000004918391,0.00903528,0.00007641812,0.9882471,0.0002166513],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008048615,0.9850212,0.001849973,0.001549334,0.002411365,0.0005502418,0.000021896,0.00001035191,0.000537038],"genre_scores_gemma":[0.0560951,0.9344987,0.004302566,0.001630694,0.002076034,0.00009090189,0.00001800494,0.00007433643,0.001213637],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9783183,"threshold_uncertainty_score":0.6139647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02350686037204543,"score_gpt":0.3190392704097241,"score_spread":0.2955324100376787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}