{"id":"W2114890848","doi":"10.2147/ott.s62717","title":"Transcriptional targeting of sphingosine-1- phosphate receptor S1P2 by epigallocatechin- 3-gallate prevents sphingosine-1-phosphate- mediated signaling in macrophage-differentiated HL-60 promyelomonocytic leukemia cells","year":2014,"lang":"en","type":"article","venue":"OncoTargets and Therapy","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Université du Québec à Montréal","keywords":"Neuroinflammation; Cell biology; Kinase; Signal transduction; MAPK/ERK pathway; Sphingosine kinase; p38 mitogen-activated protein kinases; Sphingosine; Cancer research; Sphingosine-1-phosphate; Biology; Receptor; Inflammation; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000235326,0.0004899388,0.0003419648,0.0002252644,0.0001427712,0.0003308998,0.0002303413,0.0002923883,0.0009319884],"category_scores_gemma":[0.0001123682,0.0001508732,0.0004569941,0.0002168689,0.0003957002,0.0001747848,0.0001937439,0.0006307702,0.0004837356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003226502,"about_ca_system_score_gemma":0.0003027684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000495723,"about_ca_topic_score_gemma":0.0007292097,"domain_scores_codex":[0.9997892,0.00003406467,0.00002624428,0.00004092207,0.0000454837,0.0000641196],"domain_scores_gemma":[0.9998841,0.00002062692,0.00003353417,0.00001759673,0.00001512973,0.00002901139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001959901,0.00003845817,0.00006595936,0.0000309301,0.00000384009,0.00002239737,0.00001582474,0.00004144478,0.9991896,0.00004156313,0.00002547924,0.0003286139],"study_design_scores_gemma":[0.00003070111,0.0003485116,0.001541911,0.000004171834,0.00001540419,0.00005761363,0.00002397855,0.0006170822,0.9962998,0.00001957875,0.001038277,0.000003101737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940587,0.001294166,0.002576541,0.0001570509,0.0000525785,0.00005254155,0.0007043018,0.0001227478,0.0009812512],"genre_scores_gemma":[0.9935189,0.0007346979,0.002027551,0.0000933344,0.00001576936,0.0000918611,0.001172343,0.00002603759,0.002319407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009319884,"threshold_uncertainty_score":0.0031178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006424711646603753,"score_gpt":0.2150370084513301,"score_spread":0.2086122968047264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}