{"id":"W2114890848","doi":"10.2147/ott.s62717","title":"Transcriptional targeting of sphingosine-1- phosphate receptor S1P2 by epigallocatechin- 3-gallate prevents sphingosine-1-phosphate- mediated signaling in macrophage-differentiated HL-60 promyelomonocytic leukemia cells","year":2014,"lang":"en","type":"article","venue":"OncoTargets and Therapy","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Université du Québec à Montréal","keywords":"Neuroinflammation; Cell biology; Kinase; Signal transduction; MAPK/ERK pathway; Sphingosine kinase; p38 mitogen-activated protein kinases; Sphingosine; Cancer research; Sphingosine-1-phosphate; Biology; Receptor; Inflammation; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009907674,0.0005461713,0.0007039045,0.0001309077,0.0001793223,0.00007374974,0.0003735942,0.0003626649,0.000162586],"category_scores_gemma":[0.00007660496,0.0004953575,0.0001924215,0.0002714742,0.0001437435,0.00003762935,0.0000759855,0.0003347387,0.000007309949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005232464,"about_ca_system_score_gemma":0.0001280505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003933762,"about_ca_topic_score_gemma":0.00001213819,"domain_scores_codex":[0.9969791,0.0002433596,0.0009126001,0.0008185005,0.0003621923,0.0006843064],"domain_scores_gemma":[0.9988369,0.00006032355,0.0004093008,0.0003288467,0.0001318772,0.0002327968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005633024,0.0001831172,0.002470065,0.0000935534,0.00014233,0.000003447218,0.0003716041,0.0005826337,0.9913216,0.00003473955,0.0002622266,0.003971408],"study_design_scores_gemma":[0.004664208,0.0003314447,0.00207134,0.0001454766,0.00003371077,0.000003108524,0.00004808904,0.002769881,0.9689077,0.0001673377,0.02027234,0.0005853467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761904,0.02127164,0.00127549,0.00007364954,0.0004782222,0.0005296111,0.00007372665,0.00004658167,0.00006068928],"genre_scores_gemma":[0.9890878,0.007930469,0.001486765,0.0002706641,0.0002583168,0.00004156776,0.0005943098,0.0001027794,0.0002273433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02241385,"threshold_uncertainty_score":0.9997498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006424711646603753,"score_gpt":0.2150370084513301,"score_spread":0.2086122968047264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}