{"id":"W2114902018","doi":"10.3109/00498251003713958","title":"Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism","year":2010,"lang":"en","type":"article","venue":"Xenobiotica","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"CYP2B6; CYP2A6; Nicotine; Phenobarbital; Genotype; Cytochrome P450; Metabolism; Pharmacology; Drug metabolism; Biology; Endocrinology; Chemistry; Internal medicine; Biochemistry; Medicine; CYP3A4; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003035466,0.0004314906,0.0005279914,0.0001246304,0.0002047287,0.00003686693,0.000384747,0.0004783719,0.002930742],"category_scores_gemma":[0.00004728262,0.0003896426,0.0001098654,0.0001306118,0.0004094382,0.00009016391,0.0002447864,0.001253485,0.0001407283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002314583,"about_ca_system_score_gemma":0.00003667088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008181578,"about_ca_topic_score_gemma":0.0000184211,"domain_scores_codex":[0.9976789,0.0002789767,0.0004898657,0.0006262748,0.0001904234,0.0007355445],"domain_scores_gemma":[0.9988106,0.0002516574,0.0001467438,0.0003292129,0.00001796808,0.0004437873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008365895,0.000496349,0.03213478,0.00001697019,0.00009354041,0.000006166928,0.0008194881,0.00002282573,0.9608421,0.00009782131,0.001072693,0.00431355],"study_design_scores_gemma":[0.00224256,0.00007493814,0.1052828,0.000004078053,0.0002040333,0.00001472875,0.0002049703,0.003849378,0.7571799,0.000651167,0.1297598,0.0005316871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918424,0.004220294,0.000008265165,0.0003138054,0.001201276,0.0004434922,0.0008895607,0.00005258256,0.001028271],"genre_scores_gemma":[0.9946773,0.002309158,0.0003089371,0.001697016,0.0003632192,0.00002560032,0.0001541253,0.00004805789,0.0004166019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2036623,"threshold_uncertainty_score":0.9998555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02731247820240882,"score_gpt":0.3276141190983923,"score_spread":0.3003016408959835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}